Recent Progress in Selective C-H Chlorination

The importance of organic chlorides in pharmaceutical, material, and synthetic chemistry has made the construction of C-Cl bonds a significant focus in organic chemistry. The cleavage and functionalization of C-H bonds with high atomic efficiency, leading to direct conversion into desired functional groups, is seen as a promising approach for creating new substances. Recent advancements in C-H bond activation/tranformation have led to the development of C-H chlorination reactions as viable alternatives to traditional halogenation methods. This review provides an overview of the progress made in C-H bond chlorination reactions over the last decade.