Prevalence and impact of microvascular complications in type 2 diabetes mellitus on cognitive impairment and depression: a systematic review and meta-analysis

被引：0

作者：

Satapathy, Prakasini ^{[1
,2
]}

Pratima, Pandey ^{[3
]}

Gaidhane, Abhay M. ^{[4
]}

Vadia, Nasir ^{[5
]}

Menon, Soumya V. ^{[6
]}

Chennakesavulu, Kattela ^{[7
]}

Panigrahi, Rajashree ^{[8
]}

Shabil, Muhammed ^{[9
,10
]}

Jena, Diptismita ^{[11
,12
]}

Kumar, Harish ^{[13
]}

Rani, Anju ^{[14
]}

Sah, Sanjit ^{[15
,16
,17
]}

Singh, Mahendra Pratap ^{[18
]}

Mawejje, Edward ^{[19
]}

Bushi, Ganesh ^{[20
]}

机构：

[1] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India

[2] INTI Int Univ, Fac Data Sci & Informat Technol, Nilai, Malaysia

[3] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharm Practice, Sas Nagar, Punjab, India

[4] Datta Meghe Inst Higher Educ, Global Hlth Acad, Jawaharlal Nehru Med Coll, Sch Epidemiol & Publ Hlth, Wardha, India

[5] Marwadi Univ, Res Ctr, Fac Hlth Sci, Dept Pharmaceut Sci, Rajkot 360003, Gujarat, India

[6] JAIN, Sch Sci, Dept Chem & Biochem, Bangalore, Karnataka, India

[7] Sathyabama Inst Sci & Technol, Dept Chem, Chennai, Tamil Nadu, India

[8] Siksha O Anusandhan, IMS & SUM Hosp, Dept Microbiol, Bhubaneswar 751003, Odisha, India

[9] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, Punjab, India

[10] Al Mustaqbal Univ, Med Labs Tech Dept, Hillah 51001, Babil, Iraq

[11] Chitkara Univ, Ctr Res Impact & Outcome, Rajpura 140417, Punjab, India

[12] Uttaranchal Univ, Div Res & Innovat, Dehra Dun, India

[13] New Delhi Inst Management, Tughlakabad Inst Area, New Delhi, India

[14] Graph Era, Dept Microbiol, Dehra Dun 248002, India

[15] Dr DY Patil Vidyapeeth, Dr DY Patil Med Coll Hosp, Dept Paediat & Res Ctr, Pune 411018, Maharashtra, India

[16] Dr DY Patil Vidyapeeth, Dr DY Patil Med Coll Hosp & Res Ctr, Dept Publ Hlth Dent, Pune 411018, Maharashtra, India

[17] Korea Univ, Dept Med, Seoul, South Korea

[18] Chitkara Univ, Chitkara Ctr Res & Dev, Kalujhanda 174103, Himachal Prades, India

[19] Makerere Univ, Sch Publ Hlth, Coll Hlth Sci, Mulago Hill, Kampala, Uganda

[20] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, India

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2025年 / 17卷 / 01期

关键词：

Diabetes complications; Mental health; Retinopathy; Neuropathy; Depression; Systematic review; Meta-analysis; RISK; DEMENTIA; DISEASE; STROKE;

D O I：

10.1186/s13098-025-01759-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundType 2 diabetes mellitus (T2DM) is a global health burden, often leading to microvascular complications such as neuropathy, retinopathy, and nephropathy. These complications may contribute to cognitive impairment and depression, further complicating disease management and adversely affecting quality of life. This systematic review and meta-analysis aimed to assess the prevalence and association between diabetic microvascular complications and cognitive impairment and depression among individuals with T2DM.MethodsA systematic search of PubMed, Embase, and Web of Science was conducted through November 15, 2024, following PRISMA guidelines. Observational studies examining the association between microvascular complications and mental health outcomes were included. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) scale. Meta-analyses were performed using standard statistical software, with pooled odds ratios (ORs) and 95% confidence intervals (CIs) calculated.ResultsOut of 5,640 articles screened, 7 studies met inclusion criteria. The prevalence of cognitive impairment was 34.9% in patients with neuropathy, 55.29% with retinopathy, and 40.97% with nephropathy. Depression prevalence was 43.30% for neuropathy, 40.17% for retinopathy, and 18.92% for nephropathy. Associations with cognitive impairment showed ORs of 0.878 (95% CI, 0.298-2.585) for neuropathy, 1.358 (95% CI, 0.957-1.927) for retinopathy, and 1.421 (95% CI, 1.086-1.858) for nephropathy. For depression, ORs were 1.291 (95% CI, 0.613-2.721) for retinopathy and 6.200 (95% CI, 0.029-1305.771) for neuropathy.ConclusionMicrovascular complications in T2DM contribute substantially to the burden of cognitive impairment and depression, with nephropathy showing a particularly strong link to cognitive decline. Standardized assessment approaches are needed, and integrated mental health care should be prioritized in the management of individuals with diabetes.Clinical trial numberNot applicable.

引用

页数：9

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