Diagnosis and treatment of metabolic dysfunction-associated fatty liver disease -related hepatocellular carcinoma

被引：0

作者：

Xiong, Ke-Gong ^{[1
]}

Lin, Tai-Shun ^{[1
]}

Lin, Qing-Biao ^{[1
]}

Kong, Jin-Feng ^{[1
]}

Ke, Kun-Yu ^{[1
]}

机构：

[1] Fujian Med Univ, Dept Hepatol, Mengchao Hepatobiliary Hosp, 312 Xihong Rd, Fuzhou 350025, Peoples R China

来源：

EGYPTIAN LIVER JOURNAL | 2025年 / 15卷 / 01期

关键词：

Metabolic dysfunction-associated fatty liver disease; Hepatocellular carcinoma; Diagnosis; Treatment; NONALCOHOLIC STEATOHEPATITIS; UNITED-STATES; HCC; TRANSPLANTATION; CIRRHOSIS; SURVIVAL; VETERANS; OBESITY; NAFLD; RISK;

D O I：

10.1186/s43066-025-00416-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

With the escalating global prevalence of obesity and metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as the predominant chronic liver disease worldwide, which can ultimately result in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Currently, with the effective control of viral hepatitis, MAFLD is emerging as an increasingly significant etiology for HCC. Despite the distinctive characteristics of MAFLD-related HCC (MAFLD-HCC) compared to other etiologies of HCC, its current etiology is not universally considered in all international clinical practice guidelines for HCC. In this review, we provide an overview of the prevalence, diagnostic criteria, challenges in early detection, and current treatment strategies for MAFLD-HCC. This comprehensive analysis aims to enhance understanding of MAFLD-HCC and optimize clinical management to improve patient prognosis.

引用

页数：8

共 78 条

[1] 2018 Annual Report of the European Liver Transplant Registry (ELTR)-50-year evolution of liver transplantation [J].

Adam, Rene ;

Karam, Vincent ;

Cailliez, Valerie ;

Grady, John G. O. ;

Mirza, Darius ;

Cherqui, Daniel ;

Klempnauer, Jurgen ;

Salizzoni, Mauro ;

Pratschke, Johann ;

Jamieson, Neville ;

Hidalgo, Ernest ;

Paul, Andreas ;

Lopez Andujar, Rafael ;

Lerut, Jan ;

Fisher, Lutz ;

Boudjema, Karim ;

Fondevila, Constantino ;

Soubrane, Olivier ;

Bachellier, Philippe ;

Pinna, Antonio D. ;

Berlakovich, Gabriela ;

Bennet, William ;

Pinzani, Massimo ;

Schemmer, Peter ;

Zieniewicz, Krzysztof ;

Jimenez Romero, Carlos ;

De Simone, Paolo ;

Ericzon, Bo-Goran ;

Schneeberger, Stefan ;

Wigmore, Stephen J. ;

Fabregat Prous, Joan ;

Colledan, Michele ;

Porte, Robert J. ;

Yilmaz, Sezai ;

Azoulay, Daniel ;

Pirenne, Jacques ;

Line, Pal-Dag ;

Trunecka, Pavel ;

Navarro, Francis ;

Valdivieso Lopez, Andres ;

De Carlis, Luciano ;

Rufian Pena, Sebastian ;

Kochs, Eberhard ;

Duvoux, Christophe .

TRANSPLANT INTERNATIONAL, 2018, 31 (12) :1293-1317

[2] Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: A clinical and pathological study [J].

Alexander, Jacob ;

Torbenson, Michael ;

Wu, Tsung-Teh ;

Yeh, Matthew M. .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 (05) :848-854

[3] Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts [J].

Alexander, Myriam ;

Loomis, A. Katrina ;

van der Lei, Johan ;

Duarte-Salles, Talita ;

Prieto-Alhambra, Daniel ;

Ansell, David ;

Pasqua, Alessandro ;

Lapi, Francesco ;

Rijnbeek, Peter ;

Mosseveld, Mees ;

Waterworth, Dawn M. ;

Kendrick, Stuart ;

Sattar, Naveed ;

Alazawi, William .

BMC MEDICINE, 2019, 17 (1)

[4] From NASH to HCC: current concepts and future challenges [J].

Anstee, Quentin M. ;

Reeves, Helen L. ;

Kotsiliti, Elena ;

Govaere, Olivier ;

Heikenwalder, Mathias .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (07) :411-428

[5] Epidemiology, pathophysiology and clinical aspects of Hepatocellular Carcinoma in MAFLD patients [J].

Argenziano, Maria Eva ;

Kim, Mi Na ;

Montori, Michele ;

Di Bucchianico, Alessandro ;

Balducci, Daniele ;

Ahn, Sang Hoon ;

Baroni, Gianluca Svegliati .

HEPATOLOGY INTERNATIONAL, 2024, 18 (SUPPL 2) :922-940

[6] Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Meta-Analysis and International Stereotactic Radiosurgery Society Practice Guidelines [J].

Bae, Sun Hyun ;

Chun, Seok-Joo ;

Chung, Joo-Hyun ;

Kim, Eunji ;

Kang, Jin-Kyu ;

Jang, Won Il ;

Moon, Ji Eun ;

Roquette, Isaure ;

Mirabel, Xavier ;

Kimura, Tomoki ;

Ueno, Masayuki ;

Su, Ting-Shi ;

Tree, Alison C. ;

Guckenberger, Matthias ;

Lo, Simon S. ;

Scorsetti, Marta ;

Slotman, Ben J. ;

Kotecha, Rupesh ;

Sahgal, Arjun ;

V. Louie, Alexander ;

Kim, Mi-Sook .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2024, 118 (02) :337-351

[7] Characteristics and outcome of hepatocellular carcinoma in patients with NAFLD without cirrhosis [J].

Bengtsson, Bonnie ;

Stal, Per ;

Wahlin, Staffan ;

Bjorkstrom, Niklas K. ;

Hagstrom, Hannes .

LIVER INTERNATIONAL, 2019, 39 (06) :1098-1108

[8] Hepatocellular carcinoma in non-alcohol fatty liver disease - changing trends and specific challenges [J].

Berkan-Kawinska, Aleksandra ;

Piekarska, Anna .

CURRENT MEDICAL RESEARCH AND OPINION, 2020, 36 (02) :235-243

[9] Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].

Bray, Freddie ;

Laversanne, Mathieu ;

Sung, Hyuna ;

Ferlay, Jacques ;

Siegel, Rebecca L. ;

Soerjomataram, Isabelle ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2024, 74 (03) :229-263

[10] Post-transplantation outcome in non-alcoholic steatohepatitis cirrhosis: Comparison with alcoholic cirrhosis [J].

Castello, Beatriz ;

Aguilera, Victoria ;

Teresa Blazquez, M. ;

Rubin, Angel ;

Garcia, Maria ;

Vinaixa, Carmen ;

Benlloch, Salvador ;

SanJuan, Fernando ;

Montalva, Eva ;

Lopez, Rafael ;

Berenguer, Marina .

ANNALS OF HEPATOLOGY, 2019, 18 (06) :855-861

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