Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults

被引：0

作者：

Elnahal, Ayat Shaban Mousa ^{[1
]}

Ibrahim, Ali ^{[2
]}

Abdelhalim, Elsayed ^{[2
]}

Essawy, Sally Hassan ^{[1
]}

Behiry, Ahmed ^{[2
]}

Saadoun, Mo'men ^{[3
]}

Nosair, Nahla ^{[3
]}

Abdelmonsef, Hebatallah Abdelmaksoud ^{[4
]}

Nabeeh, Hossam ^{[2
]}

Abdelbaky, Tarek ^{[2
]}

Taha, Diaa-Eldin ^{[2
]}

机构：

[1] Kafrelsheikh Univ, Fac Med, Med Microbiol & Immunol Dept, Kafrelsheikh, Egypt

[2] Kafrelsheikh Univ, Fac Med, Urol Dept, Kafrelsheikh 33155, Egypt

[3] Kafrelsheikh Univ, Fac Med, Dept Clin Pathol, Kafrelsheikh 33155, Egypt

[4] Kafrelsheikh Univ, Fac Med, Community Med Dept, Kafrelsheikh 33155, Egypt

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Pyelonephritis; Neutrophil gelatinase-associated Lipocalin; Biomarker; Urinary tract infection; URINARY-TRACT-INFECTIONS; ACID RENAL SCINTIGRAPHY; INFANTS; NGAL; IRON; LONG;

D O I：

10.1038/s41598-025-03646-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged >= 20 years suspected of having acute pyelonephritis and 66 age and sex matched participants don't have pyelonephritis. Acute Pyelonephritis was diagnosed in patients with fever, chills or the costovertebral angle tenderness, and bacteriuria higher than 105 CFU/mL without any other focus of infection. No statistically significant differences were observed between the pyelonephritis and non-pyelonephritis groups regarding demographic data or comorbidities. However, the pyelonephritis group exhibited statistically significant differences in Serum NGAL levels, abnormal urine analysis findings, total leukocyte count, and serum C-reactive protein (CRP) levels, with p-values less than 0.001. This study aims to evaluate the potential of Serum NGAL as an early diagnostic biomarker for pyelonephritis, offering a promising tool for timely and accurate diagnosis.

引用

页数：9

共 40 条

[1]

Arifin W., 2024, PREPRINT

[2]

Bauelos-Andro L., 2017, Revista Espaola De Med. Nuclear E Imagen Mol. (English Edition), V36, P2

[3] Imaging of urinary tract infection in the adult [J].

Browne, RFJ ;

Zwirewich, C ;

Torreggiani, WC .

EUROPEAN RADIOLOGY, 2004, 14 :E168-E183

[4] Asymptomatic bacteriuria among the elderly residents of long-term care facilities in Taiwan [J].

Chang, Hsiao-Ting ;

Juang, Shiow-Jen ;

Liang, Yao-Jen ;

Lin, Ming-Hwai ;

Ho, Mei-Man ;

Chen, Chun-Ku ;

Hwang, Shinn-Jang .

AGE AND AGEING, 2012, 41 (06) :795-798

[5]

elsadek A., 2020, Zagazig Univ. Med. J, V0, P0, DOI [10.21608/zumj.2020.30518.1854, DOI 10.21608/ZUMJ.2020.30518.1854]

[6] Dendritic Cell-Secreted Lipocalin2 Induces CD8+ T-Cell Apoptosis, Contributes to T-Cell Priming and Leads to a TH1 Phenotype [J].

Floderer, Melanie ;

Prchal-Murphy, Michaela ;

Vizzardelli, Caterina .

PLOS ONE, 2014, 9 (07)

[7] Neutrophil gelatinase-associated lipocalin: utility in urologic conditions [J].

Forster, Catherine S. ;

Devarajan, Prasad .

PEDIATRIC NEPHROLOGY, 2017, 32 (03) :377-381

[8] The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition [J].

Goetz, DH ;

Holmes, MA ;

Borregaard, N ;

Bluhm, ME ;

Raymond, KN ;

Strong, RK .

MOLECULAR CELL, 2002, 10 (05) :1033-1043

[9] The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections [J].

Haley, Emery ;

Luke, Natalie ;

Mathur, Mohit ;

Festa, Richard A. ;

Wang, Jimin ;

Jiang, Yan ;

Anderson, Lori A. ;

Baunoch, David .

RESEARCH AND REPORTS IN UROLOGY, 2024, 16 :19-29

[10] Acute Pyelonephritis in Adults [J].

Johnson, James R. ;

Russo, Thomas A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (01) :48-59

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