Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement

被引：0

作者：

Shi, Jiahong ^{[1
]}

Wang, Lulu ^{[2
]}

Shan, Liliang ^{[1
]}

Zhu, Meng ^{[3
]}

Chen, Yu ^{[4
]}

Li, Houxuan ^{[1
]}

Lei, Lang ^{[2
]}

机构：

[1] Nanjing Univ, Nanjing Stomatol Hosp, Affiliated Hosp, Inst Stomatol,Med Sch,Dept Periodont, Nanjing, Peoples R China

[2] Nanjing Univ, Nanjing Stomatol Hosp, Affiliated Hosp, Inst Stomatol,Med Sch,Dept Orthodont, Nanjing, Peoples R China

[3] Ningxia Med Univ, Stomatol Hosp Gen Hosp, Dept Orthodont, Yinchuan, Ningxia Hui Aut, Peoples R China

[4] Peoples Hosp Longhua, Dept Dent, Shenzheng, Peoples R China

来源：

PROGRESS IN ORTHODONTICS | 2025年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Gingival crevicular fluid; Orthodontic tooth movement; Succinate; Succinate receptor; Bone remodeling; CREVICULAR FLUID; REPERFUSION INJURY; ACCUMULATION; EXPRESSION; IL-1-BETA; CYTOKINES;

D O I：

10.1186/s40510-025-00563-5

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectiveThis study aimed to elucidate metabolic alterations in gingival crevicular fluid (GCF) during orthodontic tooth movement (OTM) and investigate the role of the succinate-SUCNR1 axis in bone resorption and tooth movement.ResultsOTM was accompanied by the change of TCA cycle and increase of succinate in the human GCF. Succinate accumulation was observed in periodontal ligament cells (PDLCs) under compressive force, accompanied by increase of glycolysis and decrease of succinic dehydrogenase activity. Suppression of the succinate-SUCNR1 axis reduced osteoclastogenesis in BMDMs. OTM slowed down in the SUCNR1-/- mice when compared with wild mice.ConclusionOTM is accompanied by the increase of succinate in periodontal tissues. Compressive force induces metabolic reprogramming in PDLCs, leading to enhanced succinate production. Succinate promotes macrophage migration and osteoclast differentiation via the SUCNR1 axis, ultimately facilitating orthodontic tooth movement. These findings provide a new potential therapeutic target for regulating periodontal tissue remodeling during orthodontic treatment.

引用

页数：14

共 32 条

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