Disinfection methods for preventing COVID-19 infections in healthcare settings: A rapid review

Background: Disinfectant sprays and wipes reduce the risk of infection from contaminated surfaces and materials in healthcare facilities. To support guideline updates, evidence on surface disinfection against the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection are needed. Aim: This study aims to compare the effect of disinfection by spraying or wiping on the risk of human infections in healthcare facilities providing coronavirus disease 2019 (COVID-19) services. Setting: Healthcare settings providing care for patients with COVID-19 or where exposure risk to COVID-19 is high. Method: We searched the Central Register of Controlled Trials (CENTRAL) and Cochrane Database of systematic review; PubMed, EMBASE and EPOC databases from 01 January 2020 to 31 August 2022. Results were screened for eligibility, the risk of bias in included studies assessed, and the certainty of evidence defined using GRADE (R). Results: Three observational studies were included. Two studies reporting proportion of surfaces with residual contamination, showed contrasting results with spraying more effective (0%, [n = 0/39] vs. 25.6% [n = 23/90]) in one study but less effective (25.0% [n = 12/48] vs. 48.2% [n = 13/27]) in the other. The third study reported higher reductions from wiping (88.0%) compared to spraying (15.1%). The risk of bias ranged from moderate to serious and the certainty of the evidence was very low. No study reported a direct effect on the risk of infection in humans. Conclusion: Both spraying and wiping methods may protect against SARS-CoV-2 infections indirectly by reducing residual surface contamination. Contribution: The use of both methods of disinfection in cleaning protocols indirectly reduces residual surface contamination.