Recent advances in electrochemiluminescence sensing for in vitro cell analysis: a review

被引：0

作者：

Ino, Kosuke ^{[1
]}

Mockaitis, Tomas ^{[1
,2
]}

Shikuwa, Ryota ^{[1
]}

Oba, Kimiharu ^{[1
]}

Hiramoto, Kaoru ^{[3
,4
]}

Morkvenaite-Vilkonciene, Inga ^{[2
,5
]}

Abe, Hiroya ^{[1
,3
]}

Shiku, Hitoshi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Engn, Sendai 9808579, Japan

[2] Ctr Phys Sci & Technol, State Res Inst, Dept Nanotechnol, Lab Bioelectrochem Technol, LT-10257 Vilnius, Lithuania

[3] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Sendai 9808577, Japan

[4] Tohoku Univ, Res Inst Elect Commun, Sendai 9808577, Japan

[5] Vilnius Gediminas Tech Univ, Dept Elect Engn, LT-10223 Vilnius, Lithuania

来源：

ANALYTICAL SCIENCES | 2025年 / 41卷 / 05期

基金：

日本学术振兴会;

关键词：

Electrochemiluminescence; Cell analysis; Luminol/H2O2; system; Ru(bpy)(3)](2+)/tri-n-propylamine system; Bipolar electrochemistry; SCANNING ELECTROCHEMICAL MICROSCOPY; CLOSED BIPOLAR ELECTRODE; ELECTROGENERATED CHEMILUMINESCENCE; HYDROGEN-PEROXIDE; NITRIC-OXIDE; SYSTEMS; VISUALIZATION; LUMINESCENCE; DEVICES; ARRAYS;

D O I：

10.1007/s44211-025-00723-x

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Electrochemiluminescence (ECL) is a chemiluminescence phenomenon triggered by electrochemical reactions and is widely used for (bio)chemical analyses and electrochemical bioimaging. Compared to fluorescence sensing, ECL sensing reduces background noise by eliminating autofluorescence associated with excitation light. In addition, compared with conventional electrochemical imaging with scanning electrochemical microscopes, ECL imaging is faster as it requires no scanning. Furthermore, unlike electrode arrays, ECL devices can function without complex wiring, simplifying their construction. These characteristics render ECL sensing a useful analytical tool. Recently, ECL sensing has been widely used for in vitro cell analysis due to high demand for biochips in regenerative medicine, drug screening, and microphysiological systems. This review focuses on recent advancements in ECL-based cell analysis with applications for the detection of H2O2, respiration activity, cell adhesion, lipid membranes, and bipolar electrochemistry-based devices.

引用

页码：557 / 569

页数：13

共 108 条

[1] Electrochemiluminescence Imaging Based on Bipolar Electrochemistry Using Commercially Available Anisotropic Conductive Films [J].