Synthesis and study of anti-inflammatory activity of N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides

被引：0
作者：
Denisova, E. I. [1 ]
Zvereva, O. V. [1 ]
Lipin, D. V. [2 ]
Chashchina, S. V. [1 ]
Chernov, I. N. [3 ]
Denislamova, E. S. [4 ]
Shipilovskikh, D. A. [4 ,5 ]
Igidov, N. M. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Minist Hlth Russian Federat, 101 ul Ekaterininskaya, Perm 614990, Russia
[2] ITMO Univ, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia
[3] Natl Res Lobachevsky State Univ Nizhny Novgorod, 23 prosp Gagarina, Nizhnii Novgorod 603950, Russia
[4] Perm Natl Res Polytech Univ, 29 Komsomolsky prosp, Perm 614990, Russia
[5] Peter Great St Petersburg Polytech Univ, 29 ul Politekhnicheskaya, St Petersburg 195251, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2025年 / 74卷 / 04期
关键词：
2,4-dioxobutanoic acids; hydrazides; amines; furan-2(3H)-ones; anti-inflammatory activity; CAP-SNATCHING ENDONUCLEASE; ANTINOCICEPTIVE ACTIVITY; ANALGESIC ACTIVITY; INTRAMOLECULAR CYCLIZATION; BIOLOGICAL-ACTIVITIES; ACUTE TOXICITY; DESIGN; DERIVATIVES; CHEMISTRY; ESTERS;
D O I：
10.1007/s11172-025-4606-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The oxofuran ring opening of 4-substituted N '-(5-aryl-2-oxofuran-3(2H)-ylidene)-benzhydrazides upon the reaction with different alkylamines gave new modified N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides. The synthesized compounds demonstrated pronounced anti-inflammatory activity in vivo and proved themselves as promising drug candidates for the treatment of inflammation.
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收藏
页码：1130 / 1137
页数：8
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