Synthesis and study of anti-inflammatory activity of N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides

被引：0

作者：

E. I. Denisova ^{[1
]}

O. V. Zvereva ^{[1
]}

D. V. Lipin ^{[2
]}

S. V. Chashchina ^{[1
]}

I. N. Chernov ^{[3
]}

E. S. Denislamova ^{[4
]}

D. A. Shipilovskikh ^{[4
]}

N. M. Igidov ^{[5
]}

机构：

[1] Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation,

[2] ITMO University,undefined

[3] National Research Lobachevsky State University of Nizhny Novgorod,undefined

[4] Perm National Research Polytechnic University,undefined

[5] Peter the Great St. Petersburg Polytechnic University,undefined

来源：

Russian Chemical Bulletin | 2025年 / 74卷 / 4期

关键词：

2,4-dioxobutanoic acids; hydrazides; amines; furan-2(3; )-ones; anti-inflammatory activity;

D O I：

10.1007/s11172-025-4606-6

中图分类号：

学科分类号：

摘要：

The oxofuran ring opening of 4-substituted N′-(5-aryl-2-oxofuran-3(2H)-ylidene)-benzhydrazides upon the reaction with different alkylamines gave new modified N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides. The synthesized compounds demonstrated pronounced anti-inflammatory activity in vivo and proved themselves as promising drug candidates for the treatment of inflammation.

引用

页码：1130 / 1137

页数：7