Luminescent Platinum(II) Complexes Featuring Innocent Pyridine-2-aldoxime Ligand: Synthesis, Characterization, and Exploration of Their In Vitro Cytotoxicity Properties

被引：2

作者：

Jadab, Madhusmita ^{[1
,2
]}

Pradhan, Kahnu Charan ^{[1
,2
]}

Behera, Suvasmita ^{[1
,2
]}

Agrawalla, Suraj Kumar ^{[3
]}

Barik, Sahadev ^{[3
]}

Purohit, Chandra Shekhar ^{[3
]}

Samanta, Snigdha ^{[4
]}

Santra, Manas Kumar ^{[4
]}

Kumar, Jagadish ^{[5
]}

Pal, Satyanarayan ^{[1
,2
]}

机构：

[1] Utkal Univ, Dept Chem, Bhubaneswar 751004, Odisha, India

[2] Utkal Univ, Ctr Adv Mat & Applicat, Bhubaneswar 751004, Odisha, India

[3] Natl Inst Sci Educ & Res, Sch Chem Sci, Bhubaneswar 752050, Odisha, India

[4] Natl Ctr Cell Sci, NCCS Complex,Pune Univ Campus Ganesh Khind, Pune 411007, Maharashtra, India

[5] Utkal Univ, Dept Phys, Bhubaneswar 751004, Odisha, India

来源：

CHEMISTRYSELECT | 2025年 / 10卷 / 17期

关键词：

Anticancer; Gel electrophoresis; Luminescence; Pt(II) Complexes; Pyridine-2-aldoxime; CHEMISTRY; BEHAVIOR;

D O I：

10.1002/slct.202500328

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new Pt(II) complexes (Pt1-Pt3) of general formula [Pt(C<^>N)(pyrald)] {where C<^>N = 2-phenylpyridine (ppy), 2-(2,4-difluorophenyl)pyridine (F2ppy) and dibenzo[a,c]phenazine (phthquinox)} were synthesised to explore the possibility of non-innocent behavior of coordinated pyridine-2-aldoxime (pyrald) and metallodrug properties of new complexes. Pt1-Pt3 were prepared in mild conditions and purified using the column chromatographic method. The complexes were thoroughly characterized by different spectroscopic and analytical techniques. The anticancer properties of the complexes (Pt1-Pt3) were explored against two breast cancer cell lines, MCF-7 and MDA-MB-231 and the results revealed the inhibition of cancer cell proliferation at very low concentrations of all the complexes. Experimentally, the interactions of Pt1-Pt3 with DNA were also evaluated using electrophoresis techniques. TD-DFT calculations were performed on these new complexes for insightful analysis of their electrochemical and optical properties.

引用

页数：10

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