Global trends and burden of brain and central nervous system cancers in adolescents and young adults GBD 2021 study

被引：0

作者：

Bin Huangfu ^{[1
]}

Xuanchen Liu ^{[2
]}

Xiao Wang ^{[4
]}

Xiaochen Niu ^{[1
]}

Chunhong Wang ^{[2
]}

Rui Cheng ^{[1
]}

Hongming Ji ^{[2
]}

机构：

[1] Shanxi Medical University,The Neurosurgery Department of Shanxi Provincial People’s Hospital

[2] Shanxi Provincial People’s Hospital,Linfen People’s Hospital

[3] RWTH Aachen University,undefined

[4] The Seventh Clinical School of Shanxi Medical University,undefined

来源：

Scientific Reports | / 15卷 / 1期

关键词：

CNS cancers; Adolescents and young adults; Global burden of disease; Incidence; Mortality; DALYs; Bayesian Age-Period-Cohort model; Health disparities; Socio-Demographic index;

D O I：

10.1038/s41598-025-01368-6

中图分类号：

学科分类号：

摘要：

Brain and central nervous system (CNS) cancers are a major cause of cancer-related mortality and morbidity among adolescents and young adults (AYAs) aged 15–39, presenting significant global health challenges despite advances in treatment. This study assesses the global burden and future trends of CNS cancers in AYAs using data from the Global Burden of Disease (GBD) 2021 database. Data on incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 were analyzed for 204 countries and territories. Age-standardized rates for incidence (ASIR), mortality (ASMR), and DALYs (ASDR) were calculated, with temporal trends assessed using Joinpoint regression and future projections estimated using the Bayesian Age-Period-Cohort (BAPC) model. Disparities were evaluated using the Socio-Demographic Index (SDI), a composite measure of income, education, and fertility rates. In 2021, global CNS cancer incidence among AYAs was 57,645 cases, with a prevalence of 271,770. The ASIR was 1.92 per 100,000, the ASMR 0.95 per 100,000, and DALYs totaled 1,744,650. High-SDI regions reported higher ASIR but lower ASMR and ASDR. By 2040, case numbers are projected to rise, while age-standardized rates may stabilize or decline. This study highlights significant global disparities in CNS cancer burden, calling for investments in cancer registries, equitable healthcare access, and tailored prevention and treatment strategies.

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