Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration

被引：0

作者：

Parastoo Noory ^{[1
]}

Ahmad Reza Farmani ^{[2
]}

Jafar Ai ^{[1
]}

Naghmeh Bahrami ^{[1
]}

Mohammad Bayat ^{[3
]}

Somayeh Ebrahimi-Barough ^{[3
]}

Ali Farzin ^{[1
]}

Shima Shojaie ^{[4
]}

Hamed Hajmoradi ^{[5
]}

Abdolreza Mohamadnia ^{[6
]}

Arash Goodarzi ^{[7
]}

机构：

[1] Tehran University of Medical Sciences,Department of Tissue Engineering, School of Advanced Technologies in Medicine

[2] Fasa University of Medical Sciences,Department of Tissue Engineering, School of Advanced Technologies in Medicine

[3] Tehran University of Medical Sciences,Craniomaxillofacial Research Center

[4] Tarbiat Modares University,Material Engineering Department, Faculty of Engineering

[5] Tehran University of Medical Sciences,Faculty of Medicine

[6] Kashan University of Medical Sciences,Department of Internal Medicine, School of Medicine

[7] Shahid Beheshti University of Medical Sciences,Department of Biotechnology, School of Advanced Technologies in Medicine

[8] Shahid Beheshti University of Medical Sciences,Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD)

来源：

Journal of Biological Engineering | / 19卷 / 1期

关键词：

3D printing; Layer-by-layer; Polycaprolactone; Nano-Hydroxyapatite; Alginate; Gelatin; Bone tissue engineering; Endometrium-derived mesenchymal stem cells;

D O I：

10.1186/s13036-025-00514-y

中图分类号：

学科分类号：

摘要：

Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel).

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