Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery

被引：6
作者：
Sabit, Hussein [1 ]
Pawlik, Timothy M. [2 ]
Radwan, Faisal [3 ]
Abdel-Hakeem, Mohamed [4 ]
Abdel-Ghany, Shaimaa [5 ]
Wadan, Al-Hassan Soliman [6 ]
Elzawahri, Mokhtar [1 ]
El-Hashash, Ahmed [7 ]
Arneth, Borros [8 ]
机构：
[1] Misr Univ Sci & Technol, Coll Biotechnol, Dept Med Biotechnol, POB 77, Giza, Egypt
[2] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH 43210 USA
[3] NOAA, Ctr Coastal Environm Hlth & Biomol Res, NCCOS, NOS, Charleston, SC 29412 USA
[4] Misr Univ Sci & Technol, Coll Biotechnol, Dept Pharmaceut Biotechnol, POB 77, Giza, Egypt
[5] Misr Univ Sci & Technol, Coll Biotechnol, Dept Environm Biotechnol, POB 77, Giza, Egypt
[6] Galala Univ, Fac Dent, Oral Biol Dept, Attaka 15888, Suez Governorat, Egypt
[7] Elizabeth City State Campus Univ North Carolina UN, Elizabeth, NC USA
[8] Philipps Univ Marburg, Hosp Univ Giessen & Marburg UKGM, Inst Lab Med & Pathobiochem, Mol Diagnost, Baldingerstr 1, D-35043 Marburg, Germany
来源：
MOLECULAR CANCER | 2025年 / 24卷 / 01期
关键词：
Nanomedicine; Immunotherapy; Cancer therapy; Drug delivery; Tumor microenvironment; RESPONSIVE NANOPARTICLES; CLINICAL-TRIALS; PHOTOTHERMAL THERAPY; SYSTEM; PH; ANTITUMOR; NANOPLATFORM; DOXORUBICIN; NANOVACCINE; EXOSOMES;
D O I：
10.1186/s12943-025-02357-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer treatment has been revolutionized by immunotherapy and nanomedicine, offering innovative strategies to overcome the tumor microenvironment (TME) complexities. However, challenges such as therapeutic resistance, off-target effects, and immune suppression necessitate advanced delivery systems and combination approaches. Recent advancements in nanoparticle-based therapies, biomimetic platforms, and personalized immunotherapy provide promising solutions to enhance therapeutic efficacy while minimizing systemic toxicity. This review explores recent nanoparticle-mediated immunotherapy developments, highlighting strategies to optimize drug delivery, remodel the TME, and improve patient-specific treatment outcomes. A comprehensive review of recent literature focused on nanoparticle-based drug delivery, stimuli-responsive systems, biomimetic nanoplatforms, and personalized immunotherapy approaches. The effectiveness of combination therapies integrating physical and immunological strategies was also analyzed. Nanoparticle-mediated immunotherapy enables precise targeting and controlled drug release, significantly improving therapeutic outcomes. Biomimetic nanoplatforms enhance immune modulation and drug bioavailability, while personalized immunotherapy, guided by predictive biomarkers, tailors treatment to individual patients. Advanced nanomedicine strategies, including TME remodeling, targeted genome editing, and combination immunotherapies, offer promising avenues for overcoming limitations in conventional cancer treatments. Future research should optimize nanoformulations, integrate multi-modal treatment strategies, and refine biomarker-driven personalization to enhance clinical outcomes.
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页数：37
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