This study addresses the pressing need for sustainable agricultural practices in the light of climate change and the growing global population, emphasizing the novel integration of precision agriculture and nanotechnology as a transformative approach. Employing a systematic literature review methodology, we meticulously analyzed peer-reviewed studies that focus on the applications of nanotechnology in agriculture and its impacts on sustainability. Our findings reveal that precision agriculture utilizes advanced technologies such as Geographic Information Systems and remote sensing to enhance resource efficiency, improve crop yields, and mitigate environmental degradation. In parallel, nanoparticles, including nano-fertilizers and nano-pesticides, demonstrate significant benefits in targeted nutrient delivery and pest control, leading to reduced chemical usage and minimal ecological disruption. The research highlights the importance of combining these technologies to create synergies that improve agricultural productivity while supporting ecological balance. In conclusion, our study underscores the necessity of integrating precision agriculture with nanotechnology to meet primary agricultural challenges sustainably. We recommend further exploration into the long-term implications of these technologies and their scalability for practical application in different farming contexts, advocating for collaboration among researchers, industry stakeholders, and policymakers to facilitate the adoption of these innovative strategies in agriculture for a more resilient and sustainable food system.