Human immunodeficiency virus-associated nephropathy mainly due to cellular variant of focal segmental glomerulosclerosis

被引：0

作者：

Tanimizu, Hikaru ^{[1
,3
]}

Sawa, Naoki ^{[1
]}

Sekine, Akinari ^{[1
]}

Oba, Yuki ^{[1
]}

Yamanouchi, Masayuki ^{[1
]}

Hasegawa, Eiko ^{[1
]}

Suwabe, Tatsuya ^{[1
]}

Hoshino, Junichi ^{[1
,3
]}

Kinowaki, Keiichi ^{[2
]}

Kono, Kei ^{[2
]}

Ohashi, Kenichi ^{[2
,4
]}

Kanetsuna, Yukiko ^{[5
]}

Honda, Kazuho ^{[6
]}

Joh, Kensuke ^{[7
]}

Yamaguchi, Yutaka ^{[8
]}

Wada, Takehiko ^{[1
,3
]}

Ubara, Yoshifumi ^{[1
,3
]}

机构：

[1] Toranomon Gen Hosp, Nephrol Ctr, 2-2-2 Toranomon, Tokyo 1050001, Japan

[2] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[3] Toranomon Gen Hosp, Okinaka Mem Inst Med Res, Tokyo, Japan

[4] Hosp Yokohama City Univ, Dept Pathol, Yokohama, Kanagawa, Japan

[5] Int Univ Hlth & Welf, Dept Pathol, Narita, Japan

[6] Showa Univ, Sch Med, Dept Anat, Tokyo, Japan

[7] JIKEI UNIV, Dept Pathol, Minato, Japan

[8] Yamaguchis Pathol Lab, Chiba, Japan

来源：

CEN CASE REPORTS | 2025年 / 14卷 / 03期

关键词：

Human immunodeficiency virus (HIV); Focal segmental glomerulosclerosis (FSGS); HIV-associated nephropathy; Cellular variant of FSGS; Collapsing variant of FSGS;

D O I：

10.1007/s13730-025-00979-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 45-year-old man with a low titer of hepatitis B virus (HBV) was diagnosed with nephrotic syndrome. A subsequent test for human immunodeficiency virus (HIV) was positive. Kidney biopsy revealed some signs of collapsing variant of focal segmental glomerulosclerosis (FSGS), but the predominant finding was a cellular variant of FSGS. Two years after receiving tenofovir, urine protein became negative, and the patient was finally diagnosed with HIV-associated nephropathy. Collapsing variant of FSGS is considered typical of HIV-related nephropathy, but the cellular variant of FSGS in this patient represents another type. The cause of many FSGSs is often never identified, making cause-based treatment difficult. This case demonstrates that identification of the cause of FSGS can lead to treatment of FSGS.

引用

页码：345 / 350

页数：6

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