Mesenchymal stem/stromal cells as a therapeutic for sepsis: a review on where do we stand?

被引：0

作者：

Premer, Courtney ^{[1
]}

Hare, Joshua M. ^{[2
]}

Yuan, Sarah Y. ^{[3
]}

Wilson, Jason W. ^{[4
]}

机构：

[1] Northwestern Univ, McGaw Med Ctr, Dept Emergency Med, 211 E Ontario St,Suite 200, Chicago, IL 60611 USA

[2] Univ Miami, Interdisciplinary Stem Cell Inst ISCI, Div Cardiovasc Med, Dept Med, Miami, FL USA

[3] Univ S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL USA

[4] Univ S Florida, Tampa Gen Hosp, Morsani Coll Med, Dept Emergency Med, Tampa, FL USA

来源：

STEM CELL RESEARCH & THERAPY | 2025年 / 16卷 / 01期

关键词：

Sepsis; Septic shock; Mesenchymal stem cells; MSC; Clinical trials; STEM-CELLS; STROMAL CELLS;

D O I：

10.1186/s13287-025-04371-w

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Sepsis is one of the leading causes of morbidity and mortality in the United States and Worldwide despite advances in quick recognition and early antibiotics, fluids, and vasopressors. Mesenchymal stem/stromal cells (MSCs) have gained attention as a biologic therapy given their unique anti-inflammatory, immunomodulatory, and anti-bacterial characteristics. MSCs have had success in treating a range of diseases, however limited clinical trials exist specifically for MSC use in sepsis. This article reviews the properties of MSCs that make them favorable for treating sepsis, as well as the current state of clinical trials. All clinical trials presented here demonstrated MSC safety, with a mixture of efficacy results and a heterogeneity of trial methods. Ultimately, MSCs are a promising novel therapeutic for sepsis, however a consensus in cell source, dosage, preparation, and delivery needs to be further investigated for MSCs to transition from bench to bedside and become a true therapeutic for sepsis.

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