Function of manchette and intra-manchette transport in spermatogenesis and male fertility

被引：0

作者：

Tingting Gao ^{[1
]}

Yang Liu ^{[2
]}

Jie Li ^{[1
]}

Yvxia Zhang ^{[3
]}

Bin Wu ^{[1
]}

机构：

[1] Central Hospital Affiliated to Shandong First Medical University,Department of Reproductive Medicine

[2] Jinan Central Hospital,undefined

[3] Cheeloo College of Medicine,undefined

[4] Shandong University,undefined

[5] The First People’s Hospital of Kunshan,undefined

来源：

Cell Communication and Signaling | / 23卷 / 1期

关键词：

Manchette; IMT; Spermatogenesis; Infertility; AAM axis; LINC complex;

D O I：

10.1186/s12964-025-02213-z

中图分类号：

学科分类号：

摘要：

The manchette is a transient skirt-like structure consisting of microtubules (MTs) and filamentous actin (F-actin) surrounding the elongating sperm head during spermiogenesis. It is pivotal in sperm head shaping controlled by the acrosome-acroplaxome-manchette complex, acrosome formation, and flagellar assembly by microtubular-based protein delivery. Defects in the manchette frequently lead to teratozoospermia concomitant with oligozoospermia and asthenozoospermia, but the pathogenic mechanism underlying manchette function and its role in male infertility remain poorly understood. In this review, we systematically described the assembly and disassembly of the manchette, intra-manchette transport (IMT) and its regulatory model, the function and mechanism of manchette and IMT in regulating sperm head shaping and flagellar assembly during spermatogenesis; summarized the research progress of manchette-related genes related to male infertility; and listed the manchette-related proteins in knockout mouse models and clinical cases, which provide the theoretical basis for an in-depth understanding of the molecular mechanism of manchette involved in spermatogenesis and male fertility for understanding the potentially developing treatments for infertility and reproductive disorders.

引用