Association between bone mineral density and stroke: a meta-analysis

被引:0
作者
Zhao, Peng [1 ]
Sun, Huaxia [2 ]
机构
[1] Hebei North Univ, Affiliated Hosp 2, Dept Neurol, Zhangjiakou, Hebei, Peoples R China
[2] Weifang Hosp Tradit Chinese Med, Dept Neurol, Weifang, Shandong, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2025年 / 16卷
关键词
bone density; osteoporosis; osteopenia; stroke; cerebrovascular accident; ALPHA GENE POLYMORPHISMS; ELDERLY-WOMEN; GLOBAL BURDEN; RISK; OSTEOPOROSIS; DISEASE; MORTALITY; FRACTURE; CHINA;
D O I
10.3389/fneur.2025.1561559
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The correlation between bone mineral density (BMD) and stroke remains inconsistent. This study aims to determine whether a reduction in BMD is associated with an increased risk of stroke. Methods: We systematically searched Medline, Embase, and the Cochrane Database of Systematic Reviews through January 2025 to identify cohort studies with follow-up that reported the influence of a reduction in BMD or low BMD status on the risk of any type of stroke. Pooled analyses were performed using random-effects models. Results: This study included 13 studies with 146,758 individuals. A 1 SD reduction in BMD was associated with an increased risk of stroke (eight studies; RR, 1.24; 95% CI, 1.09-1.40; p < 0.001; I-2 = 87%). Subgroup analysis showed that a per SD reduction in BMD was associated with incident stroke in female persons (eight studies; RR, 1.28; 95% CI, 1.09-1.51; p = 0.002; I-2 = 87%), but not in male persons (four studies; RR, 1.04; 95% CI, 0.99-1.10; p = 0.15; I-2 = 0%). People with osteoporosis or osteopenia had an increased risk of incident stroke (six studies; RR, 1.59; 95% CI, 1.22-2.08; p < 0.001; I-2 = 92%), as well as male persons (two studies; RR, 3.16; 95% CI, 1.96-5.12; p < 0.001; I-2 = 35%). Sensitivity analysis showed that the results were stable. Conclusion: Reduction in BMD is associated with a significantly increased risk of stroke. Female individuals have a higher risk than male persons.
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页数:10
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  • [1] Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study
    Bhatta, Laxmi
    Cepelis, Aivaras
    Vikjord, Sigrid A.
    Malmo, Vegard
    Laugsand, Lars E.
    Dalen, Havard
    Langhammer, Arnulf
    Janszky, Imre
    Strand, Linn B.
    Brumpton, Ben M.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2021, 36 (11) : 1169 - 1177
  • [2] ASSOCIATION BETWEEN LOW BONE-DENSITY AND STROKE IN ELDERLY WOMEN - THE STUDY OF OSTEOPOROTIC FRACTURES
    BROWNER, WS
    PRESSMAN, AR
    NEVITT, MC
    CAULEY, JA
    CUMMINGS, SR
    [J]. STROKE, 1993, 24 (07) : 940 - 946
  • [3] NONTRAUMA MORTALITY IN ELDERLY WOMEN WITH LOW BONE-MINERAL DENSITY
    BROWNER, WS
    SEELEY, DG
    VOGT, TM
    CUMMINGS, SR
    [J]. LANCET, 1991, 338 (8763) : 355 - 358
  • [4] Hospitalized osteoporotic vertebral fracture increases the risk of stroke: A population-based cohort study
    Chen, Yu-Chun
    Wu, Jau-Ching
    Liu, Laura
    Huang, Wen-Cheng
    Cheng, Henrich
    Chen, Tzeng-Ji
    Thien, Peck-Foong
    Lo, Su-Shun
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (03) : 516 - 523
  • [5] Cheng L., 2024, Osteoporos Int ., V35, p1289 98, DOI [10.1007/s00198-024-07123-3, DOI 10.1007/S00198-024-07123-3]
  • [6] Prediction of incident osteoporotic fractures in elderly women using the free estradiol index
    Devine, A
    Dick, IM
    Dhaliwal, SS
    Naheed, R
    Beilby, J
    Prince, RL
    [J]. OSTEOPOROSIS INTERNATIONAL, 2005, 16 (02) : 216 - 221
  • [7] Feigin VL., 2018, NEW ENGL J MED, V379, P2429, DOI [10.1056/NEJMoa1804492, DOI 10.1056/NEJMoa1804492]
  • [8] Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke
    Foroughinia, Farzaneh
    Morovati, Najmeh
    Safari, Anahid
    Dianatpour, Mehdi
    Jamhiri, Iman
    Heydari, Seyed Taghi
    Hooshmandi, Sedighe
    Borhani-Haghighi, Afshin
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2022, 97 : 115 - 120
  • [9] Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening
    Frost, Michelle L.
    Grella, Rodolpho
    Millasseau, Sandrine C.
    Jiang, Ben-yu
    Hampson, Geeta
    Fogelman, Ignac
    Chowienczyk, Phil J.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2008, 83 (02) : 112 - 120
  • [10] GA Wells BSDO, 2021, The newcastle-ottawa scale (nos) for assessing the quality of nonrandomised studies in meta-analyses