Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications

被引：1

作者：

Nicolaescu, Oana Elena ^{[1
]}

Ionescu, Catalina ^{[2
]}

Samide, Adriana ^{[2
]}

Tigae, Cristian ^{[2
]}

Spinu, Cezar Ionut ^{[2
]}

Oprea, Bogdan ^{[3
]}

机构：

[1] Univ Med & Pharm Craiova, Fac Pharm, Dept Pharmaceut Technol, 2 Petru Rares St, Craiova 200349, Romania

[2] Univ Craiova, Fac Sci, Dept Chem, 107i Calea Bucuresti, Craiova 200144, Romania

[3] Univ Med & Pharm Craiova, Fac Med, 2 Petru Rares St, Craiova 200349, Romania

来源：

PHARMACEUTICS | 2025年 / 17卷 / 04期

关键词：

cyclodextrins; natural compounds; secondary metabolites; polyphenols; terpenes and terpenoids; alkaloids; NATURAL-PRODUCTS; BETA-CYCLODEXTRIN; POLYPHENOLS; INCLUSION; DELIVERY; CAFFEINE; DRUGS;

D O I：

10.3390/pharmaceutics17040506

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic compounds. This review prioritizes the research of recent years (2022-2025), being focused on (1) systematization of the research of ICs based on the structure of the secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes and terpenoids (TTs), and (iii) alkaloids (Alks); (2) for each type of inclusion complex, the following aspects have been discussed: benefits of complexation, composite materials, and in vitro/in vivo and theoretical studies; and (3) pharmacokinetics and pharmacodynamics, risks, limitations, and perspectives of cyclodextrin inclusion complexes with secondary metabolites.

引用

页数：31

共 180 条

[1] Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices [J].

Abdelazim, Ahmed H. ;

Algarni, Majed A. ;

Almalki, Atiah H. .

SCIENTIFIC REPORTS, 2023, 13 (01)

[2] Biological Activities of Alkaloids: From Toxicology to Pharmacology [J].

Adamski, Zbigniew ;

Blythe, Linda L. ;

Milella, Luigi ;

Bufo, Sabino A. .

TOXINS, 2020, 12 (04)

[3]

Adibah K.Z.M., 2019, GSC Biological and Pharmaceutical Sciences, V6, P21, DOI DOI 10.30574/GSCBPS.2019.6.2.0003

[4] Cyclodextrins and Their Derivatives as Drug Stability Modifiers [J].

Aiassa, Virginia ;

Garnero, Claudia ;

Zoppi, Ariana ;

Longhi, Marcela R. .

PHARMACEUTICALS, 2023, 16 (08)

[5]

Ali S, 2025, J BIOMOL STRUCT DYN, V43, P2596, DOI [10.1080/07391102.2024.2305696, 10.1080/03601234.2024.2357465]

[6] Ent-kaurenoic acid-enriched Mikania glomerata leaves-complexed β-cyclodextrin: Pharmaceutical development and in vivo antitumor activity in a sarcoma 180 mouse model [J].

Alves, Angela V. F. ;

Melo, Carlisson R. ;

Chagas-Neto, Jose L. ;

Amaral, Ricardo G. ;

Ambrosio, Sergio R. ;

Moreira, Monique R. ;

Veneziani, Rodrigo C. S. ;

Cardoso, Juliana C. ;

Severino, Patricia ;

Gondak, Rogerio O. ;

Souto, Eliana B. ;

de Albuquerque-Junior, Ricardo L. C. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 631

[7] Anti-melanoma potential of inclusion complexes containing phyllacanthone in β-cyclodextrin and sulfobutyl-ether-β-cyclodextrin [J].

Alves, Cristiane dos Santos Cerqueira ;

Tavares, Yuri Kelvin Silva Camacho ;

Novaes, Guilherme Urias Menezes ;

Santos, Victoria Laysna dos Anjos ;

de Oliveira, Ana Paula ;

Leal, Cintia Emi Yanaguibashi ;

de Alencar Filho, Edilson Beserra ;

Ferraz, Christiane Adrielly Alves ;

Picot, Laurent ;

Almeida, Jackson Roberto Guedes da Silva ;

de Oliveira Jr, Raimundo Goncalves .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 89

[8]

Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044

[9] How cyclodextrin encapsulation improves molecular stability of apple polyphenols phloretin, phlorizin, and ferulic acid: Atomistic insights through structural chemistry [J].

Aree, Thammarat .

FOOD CHEMISTRY, 2023, 409

[10]

Ashiwaju B.I., 2023, MATRIX SCI PHARM, V7, P85, DOI [10.4103/mtsp.mtsp1523, DOI 10.4103/MTSP.MTSP1523, 10.4103/mtp.mup1523]

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