How Fear Memory is Updated: From Reconsolidation to Extinction?

被引：0

作者：

Chen, Jiahui ^{[1
]}

Fang, Zhuowen ^{[1
]}

Zhang, Xiaolan ^{[2
]}

Zheng, Yanrong ^{[2
]}

Chen, Zhong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Zhejiang Key Lab Neuropsychopharmacol, Hangzhou 310058, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pro, Hangzhou 310053, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2025年

基金：

中国国家自然科学基金;

关键词：

Post-traumatic stress disorder; Fear memory; Reconsolidation; Extinction; Engram; VENTROMEDIAL PREFRONTAL CORTEX; NUCLEUS BASALIS MAGNOCELLULARIS; POSTTRAUMATIC-STRESS-DISORDER; ANTERIOR CINGULATE CORTEX; LONG-TERM-MEMORY; PROTEIN-SYNTHESIS; CONDITIONED FEAR; BASOLATERAL AMYGDALA; SYSTEMIC INHIBITION; DIFFERENTIAL ROLES;

D O I：

10.1007/s12264-025-01367-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Post-traumatic stress disorder (PTSD) is a psychiatric disorder caused by traumatic past experiences, rooted in the neurocircuits of fear memory formation. Memory processes include encoding, storing, and recalling to forgetting, suggesting the potential to erase fear memories through timely interventions. Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects. This review explores how fear memory may be erased, particularly focusing on the mnemonic phases of reconsolidation and extinction. Reconsolidation strengthens memory, while extinction weakens it. Interfering with memory reconsolidation could diminish the fear response. Alternatively, the extinction of acquired memory could reduce the fear memory response. This review summarizes experimental animal models of PTSD, examines the nature and epidemiology of reconsolidation to extinction, and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD. In sum, understanding how fear memory updates holds significant promise for PTSD treatment.

引用

页码：1054 / 1084

页数：31

共 260 条

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