The Kappa Free Light Chains Index and Central Vein Sign: Two New Biomarkers for Multiple Sclerosis Diagnosis

被引：1

作者：

Levraut, Michael ^{[1
,2
]}

Landes-Chateau, Cassandre ^{[1
]}

Mondot, Lydiane ^{[1
]}

Cohen, Mikael ^{[1
]}

Lebrun-Frenay, Christine ^{[1
]}

机构：

[1] Equipe URRIS, Unite Rech Clin Cote dAzur, Nice, France

[2] Ctr Hosp Univ Nice, CRC SEP, 30 Voie Romaine, F-06002 Nice, France

来源：

NEUROLOGY AND THERAPY | 2025年 / 14卷 / 03期

关键词：

Multiple sclerosis; Radiologically isolated syndrome; Kappa free light chains index; Central vein sign; CLINICALLY ISOLATED SYNDROME; FLAIR-ASTERISK MRI; CEREBROSPINAL-FLUID; BRAIN; MS; LESIONS; 3T; PERFORMANCE; REVISIONS; ACCURACY;

D O I：

10.1007/s40120-025-00737-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

At the last European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting, Montalban and the experts' panel announced the 2024 revision of the McDonald criteria. The optic nerve has been added as a fifth dissemination in space (DIS) criteria topography among the main changes. Multiple sclerosis (MS) can be diagnosed in patients with radiologically isolated syndrome (RIS) if specific biomarkers are added to at least two of the five DIS criteria. Among the particular MS biomarkers, the kappa free light chain index (kFLC index) positivity will be added to oligoclonal band (OCB) detection to fulfill intrathecal immunoglobulin synthesis, and the central vein sign (CVS) will be able to ensure the specificity of the lesions detected on MRI scans. This review summarises the knowledge on the kFLC index and the CVS in people with MS and RIS, allowing them to be incorporated into the proposed revision of the McDonald criteria.

引用

页码：711 / 731

页数：21

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