Cardiovascular benefits of standardized Aronia melanocarpa (Michx.) Elliot extract: Insights from a short-term pilot randomized human trial and cell culture studies

被引：0

作者：

Bloch, Patrycja ^{[1
]}

Niska, Karolina ^{[1
]}

Khaidakov, Barbara ^{[1
]}

Michna, Agata ^{[1
]}

Lemke, Krzysztof ^{[1
]}

Kowalczyk, Paulina ^{[1
]}

机构：

[1] AronPharma Ltd, R&D Dept, Trzy Lipy St 3, PL- 80172 Gdansk, Poland

来源：

JOURNAL OF FUNCTIONAL FOODS | 2025年 / 127卷

关键词：

Aronia melanocarpa; Cardiovascular diseases; Polyphenols; Inflammation; Oxidative stress; Clinical trial; ENDOTHELIAL-CELLS; CHOKEBERRY JUICE; BLOOD-PRESSURE; ANTHOCYANINS; BERRY; BIOAVAILABILITY; CONSUMPTION; METABOLISM; ADHESION; DISEASE;

D O I：

10.1016/j.jff.2025.106769

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cardiovascular diseases (CVDs) remain a major global health burden, emphasizing the need for effective preventive strategies. Polyphenols in Aronia melanocarpa (AM) have emerged as promising candidates due to their potent antioxidant and anti-inflammatory properties. This study evaluated the effectiveness of standardized AM extract supplementation in mitigating CVD risk factors through a 6-week pilot randomized human trial and in vitro experiments. The human trial demonstrated significant reductions in total cholesterol, LDL cholesterol, and alanine aminotransferase (ALAT) levels in the supplemented group. In vitro studies confirmed AM extract's antiinflammatory effects, as indicated by reduced pro-inflammatory cytokines and adhesion molecules in human endothelial cells (HUVECs) and human peripheral blood mononuclear cells (PBMCs). Additionally, AM extract exhibited strong antioxidant activity and enhanced nitric oxide (NO) production in cells. These findings underscore the potential of AM extract to improve lipid profiles, vascular function, and liver health, supporting its role in CVD prevention and management.

引用

页数：10