Association between post-stroke cognitive impairment and gut microbiota in patients with ischemic stroke

被引：0

作者：

Tsung-Min Jeng ^{[1
]}

Yi-Chen Hsieh ^{[2
]}

Po-Ya Chang ^{[3
]}

Yu-Ling Li ^{[4
]}

Sung-Chun Tang ^{[5
]}

Jiann-Shing Jeng ^{[5
]}

Chaur-Jong Hu ^{[6
]}

Hung-Yi Chiou ^{[7
]}

机构：

[1] National Taiwan University,Institute of Epidemiology and Preventive Medicine, College of Public Health

[2] Taipei Medical University,Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology

[3] National Taipei University of Nursing and Health Sciences,Department of Leisure Industry and Health Promotion

[4] National Health Research Institutes,Institute of Population Health Sciences

[5] National Taiwan University Hospital,Department of Neurology

[6] Shuang Ho Hospital,Department of Neurology

[7] Taipei Medical University,Department of Neurology, School of Medicine, College of Medicine

[8] Taipei Medical University,School of Public Health, College of Public Health

[9] Taipei Medical University,undefined

来源：

Scientific Reports | / 15卷 / 1期

关键词：

Gut Microbiome; Inflammation; Ischemic stroke; Post-stroke cognitive impairment;

D O I：

10.1038/s41598-025-03068-7

中图分类号：

学科分类号：

摘要：

More than half of stroke survivors have post-stroke cognitive impairment (PSCI). The role of gut microbiota, which can communicate with the brain through the gut-brain axis and affect inflammation, has been receiving increased attention. This cross-sectional study aimed to investigate the association of PSCI, gut microbiota, and inflammatory markers. Patients with first ischemic stroke and complete 3-month and 1-year follow-up data were included and divided into PSCI and non-PSCI groups according to the Montreal Cognitive Assessment (MoCA) score at the above time points. PSCI was defined as having a MoCA less than 23 at either 3 months or 1 year, or a decrease of more than 2 points at both time points. Gut microbiota was assessed by 16 S rRNA gene sequencing and Next Generation Sequencing analysis. The inflammatory markers included interleukins (ILs), eotaxin, G-CSF, TNF-α, IFNγ, sCD40L, and MCP-1. There were 95 ischemic stroke patients (mean age, 60.5 ± 12.1 years; male, 68.4%), including 30 with PSCI and 65 with non-PSCI. In gut microbiota analysis, the PSCI group had a higher abundance of Bacteroidaceae and Clostridiaceae, and the non-PSCI group had a higher abundance of Prevotellaceae, Ruminococcaceae, Oscillibacter, and Faecalibacterium. Ruminococcaceae family under the Oscillospirales order remains significantly different in the two groups in logistic regression model adjusting confounding variables (p = 0.044). In an analysis of inflammatory markers, the plasma levels of eotaxin (p = 0.041) and IL-12p40 (p = 0.031) were significantly higher in the PSCI group than those in the non-PSCI group, and the plasma level of eotaxin was significantly positively correlated with the amount of Clostridiaceae (rho = 0.389, p = 0.045). The study found that PSCI was associated with certain gut microbiota, and these gut microbiotas correlated with the pro-inflammatory marker eotaxin. This suggests that gut microbiota might play a role in the development of cognitive impairment after ischemic stroke.

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