Formulation and evaluation of HPMC and pullulan-based rapidly dissolving films containing cilnidipine nanosuspension

Cilnidipine is used to treat hypertension. However, it has poor solubility and undergoes extensive first-pass metabolism, which leads to poor bioavailability. This work aimed to prepare rapidly dissolving films (RDFs) containing nanosuspension of CLD with HPMC and pullulan as film-formers. These RDFs deliver the drugs through the buccal mucosa and bypass the first-pass metabolism, thereby increasing bioavailability. The nanosuspension was prepared using the nanoprecipitation technique and was optimized using the CCD. The optimized formulation had an average size and zeta potential of 362.23 nm and -39.1 mV, respectively. FT-IR studies indicated no interaction between CLD and stabilizers. DSC and XRD studies confirmed reduced crystallinity of CLD. SEM revealed the capsular morphology of nanoparticles. The optimized RDFs had a 2.83 f 0.24 N/mm2 tensile strength, 11.61 f 2.87 % elongation, 17.21 f 1.06 s disintegration time, and in-vitro release of 91.77 f 6.22 % in 60 min. A more than two-fold increase in drug permeation was recorded from the CLD NS-RDF as compared to the CLD CS-RDF. The CLD NS-RDF exhibited a significant increase in AUC0-24h, Cmax, and a decrease in Tmax and MRT as compared to the CLD CS-RDF. The CLD NS-RDF also had a superior effect to control the blood pressure in rats as compared to the CLD CS-RDF.