The paradox of clozapine in Black people with treatment-resistant schizophrenia

被引：0
作者：
Whiskey, Eromona [1 ,2 ]
Bachmann, Christian [3 ]
Dzahini, Olubanke [1 ,2 ]
Taylor, David [1 ,2 ]
Oloyede, Ebenezer [1 ,4 ]
机构：
[1] Maudsley Hosp & Inst Psychiat, Pharm Dept, London, England
[2] Kings Coll London, Inst Pharmaceut Sci, London, England
[3] Univ Hosp Ulm, Dept Child & Adolescent Psychiat, Ulm, Germany
[4] Univ Oxford, Dept Psychiat, Oxford, England
来源：
NATURE MENTAL HEALTH | 2025年 / 3卷 / 04期
关键词：
BENIGN ETHNIC NEUTROPENIA; UNTREATED PSYCHOSIS; MENTAL-HEALTH; RACIAL DISPARITIES; PRESCRIPTION PATTERNS; DURATION; PATHWAYS; DISCONTINUATION; CARE; SERVICES;
D O I：
10.1038/s44220-025-00411-9
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Clozapine is currently the only licensed medication for treatment-resistant schizophrenia (TRS). Ethnic inequalities in treatment with clozapine have been described extensively, particularly regarding the effect on Black ethnic groups. Here we explore the reasons for clozapine underuse in this population, identifying potential misconceptions and providing suggestions to address these barriers.
引用
收藏
页码：402 / 407
页数：6
相关论文
共 85 条
  • [31] Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the diabetes prevention program
    Herman, William H.
    MA, Yong
    Uwaifo, Gabriel
    Haffner, Steven
    Kahn, Steven E.
    Horton, Edward S.
    Lachin, John M.
    Montez, Maria G.
    Brenneman, Tina
    Barrett-Connor, Elizabeth
    [J]. DIABETES CARE, 2007, 30 (10) : 2453 - 2457
  • [32] Association Between Race/Ethnicity and Disparities in Health Care Use Before First-Episode Psychosis Among Privately Insured Young Patients
    Heun-Johnson, Hanke
    Menchine, Michael
    Axeen, Sarah
    Lung, Khristina
    Claudius, Ilene
    Wright, Tyler
    Seabury, Seth A.
    [J]. JAMA PSYCHIATRY, 2021, 78 (03) : 311 - 319
  • [33] The Effect of Race-Ethnicity on the Comparative Effectiveness of Clozapine Among Medicaid Beneficiaries
    Horvitz-Lennon, Marcela
    Donohue, Julie M.
    Lave, Judith R.
    Alegria, Margarita
    Normand, Sharon-Lise T.
    [J]. PSYCHIATRIC SERVICES, 2013, 64 (03) : 230 - 237
  • [34] IDANPAANHEIKKILA J, 1975, LANCET, V2, P611
  • [35] Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient records
    Ingimarsson, Oddur
    MacCabe, James H.
    Haraldsson, Magnus
    Jonsdottir, Halldora
    Sigurdsson, Engilbert
    [J]. NORDIC JOURNAL OF PSYCHIATRY, 2016, 70 (06) : 450 - 455
  • [36] KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789
  • [37] Addressing Barriers to Clozapine Underutilization: A National Effort
    Kelly, Deanna L.
    Freudenreich, Oliver
    Sayer, Mackenzie A.
    Love, Raymond C.
    [J]. PSYCHIATRIC SERVICES, 2018, 69 (02) : 224 - 227
  • [38] Predictors of clozapine discontinuation in patients with schizophrenia
    Krivoy, Amir
    Malka, Liron
    Fischel, Tsvi
    Weizman, Abraham
    Valevski, Avi
    [J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2011, 26 (06) : 311 - 315
  • [39] Racial disparities in antipsychotic prescription patterns for patients with schizophrenia
    Kuno, E
    Rothbard, AB
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (04) : 567 - 572
  • [40] The impact of clozapine on hospital use: a systematic review and meta-analysis
    Land, R.
    Siskind, D.
    McArdle, P.
    Kisely, S.
    Winckel, K.
    Hollingworth, S. A.
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 2017, 135 (04) : 296 - 309
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