Stress granules: emerging players in neurodegenerative diseases

被引：0

作者：

Lin Yuan ^{[1
]}

Li-Hong Mao ^{[1
]}

Yong-Ye Huang ^{[2
]}

Tiago F. Outeiro ^{[3
]}

Wen Li ^{[4
]}

Tuane C. R. G. Vieira ^{[5
]}

Jia-Yi Li ^{[6
]}

机构：

[1] China Medical University,Laboratory of Research in Parkinson’s Disease and Related Disorders, Health Sciences Institute

[2] Northeastern University,College of Life and Health Sciences

[3] University Medical Center Göttingen,Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration

[4] Max Planck Institute for Multidisciplinary Sciences,Translational and Clinical Research Institute, Faculty of Medical Sciences

[5] Newcastle University,Institute of Medical Biochemistry Leopoldo de Meis and National Institute of Science and Technology for Structural Biology and Bioimaging

[6] Scientific Employee With an Honorary Contract at Deutsches Zentrum Für Neurodegenerative Erkrankungen (DZNE),Neural Plasticity and Repair Unit, Department of Experimental Medical Science Wallenberg Neuroscience Center, BMC

[7] Federal University of Rio de Janeiro,undefined

[8] Lund University,undefined

来源：

Translational Neurodegeneration | / 14卷 / 1期

关键词：

Liquid–liquid phase separation; Stress granules; Neurodegenerative disease; RNA-binding protein;

D O I：

10.1186/s40035-025-00482-9

中图分类号：

学科分类号：

摘要：

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG dynamics. Chronic stress, arising in association with aging, may promote persistent SGs that are difficult to disassemble, thereby acting as a potential pathological nidus for protein aggregation in neurodegenerative diseases (NDDs). In this review, we discuss the dynamics of SGs and the factors involved with SG assembly and disassembly. We also highlight the relationship among LLPS, SGs, and the pathogenesis of different NDDs. More importantly, we summarize SG assembly-disassembly, which may be a double-edged sword in the pathophysiology of NDDs. This review aims to provide new insights into the biology and pathology of LLPS, SGs, and NDDs.

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