Understanding EBV infection and EBV-associated lymphomas in children

被引：0

作者：

Chabay, P. ^{[1
,2
]}

机构：

[1] Ricardo Gutierrez Childrens Hosp, Multidisciplinary Inst Invest Pediat Pathol IMIPP, Pathol Div, Mol Biol Lab,CONICET,GCBA, Buenos Aires, Argentina

[2] Hosp Ninos Dr Ricardo Gutierrez, Div Patol, Inst Multidisciplinario Invest Patol Pediat IMIPP, CONICET,GCBA, Gallo 1330,C1425EFD, Buenos Aires, Argentina

来源：

VIROLOGY | 2025年 / 608卷

关键词：

EBV; Primary infection; Persistent infection; Lymphoma; Children; EPSTEIN-BARR-VIRUS; B-CELL LYMPHOMA; LATENT MEMBRANE-PROTEIN; PEDIATRIC HODGKIN LYMPHOMA; NATURAL-KILLER-CELLS; DEATH-LIGAND; TUMOR MICROENVIRONMENT; BURKITTS-LYMPHOMA; T-CELLS; GEOGRAPHIC-VARIATION;

D O I：

10.1016/j.virol.2025.110544

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Epstein-Barr virus (EBV) infects over 90 % of the human population, often behaving as a harmless passenger in most hosts. However, since 1997, it has been classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC) due to its causal association with several malignancies. Most studies on EBV primary infection and EBV-associated lymphomas have been performed in adults from developed countries. The complex interplay between age of acquisition and symptomatic versus asymptomatic infection is related to the subsequent risk of EBV-associated cancers or autoimmune diseases. This review discusses some characteristics of EBV infection and EBV-associated lymphomas in children from low-and middle-income regions, with a focus on the local immune response.

引用

页数：12

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