Verification of unmet medical needs in patients with juvenile idiopathic arthritis in Japan

被引：0

作者：

Shimizu, Masaki ^{[1
]}

Inoue, Eisuke ^{[2
,3
]}

Sakai, Ryoko ^{[2
,4
]}

Inoue, Yuzaburo ^{[5
]}

Mitsunaga, Kanako ^{[6
]}

Sugihara, Takahiko ^{[7
]}

Hirano, Toru ^{[8
]}

Izawa, Kazushi ^{[9
]}

Kishida, Dai ^{[10
]}

Matsushita, Masakazu ^{[11
]}

Mori, Masaaki ^{[12
,13
]}

Narazaki, Hidehiko ^{[14
]}

Nishikomori, Ryuta ^{[15
]}

Sumitomo, Shuji ^{[16
]}

Tanaka, Takayuki ^{[17
]}

Yamazaki, Susumu ^{[18
]}

Yamaji, Ken ^{[11
]}

Yokogawa, Naoto ^{[19
]}

Yoshifuji, Hajime ^{[20
]}

Miyamae, Takako ^{[4
]}

机构：

[1] Inst Sci Tokyo, Grad Sch Med & Dent Sci, Dept Pediat Perinatal & Maternal Med, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan

[2] Tokyo Womens Med Univ, Sch Med, Dept Rheumatol, Tokyo, Japan

[3] Showa Univ, Showa Univ Res Adm, Tokyo, Japan

[4] Meiji Pharmaceut Univ, Dept Publ Hlth & Epidemiol, Tokyo, Japan

[5] Chiba Univ, Grad Sch Med, Dept Gen Med Sci, Chiba, Japan

[6] Chiba Childrens Hosp, Dept Allergy & Rheumatol, Chiba, Japan

[7] Toho Univ, Sch Med, Dept Internal Med, Div Rheumatol, Tokyo, Japan

[8] Nishinomiya Municipal Cent Hosp, Dept Rheumatol, Nishinomiya, Hyogo, Japan

[9] Kyoto Univ, Fac Med, Dept Pediat, Kyoto, Japan

[10] Shinshu Univ, Sch Med, Dept Med Neurol & Rheumatol, Matsumoto, Japan

[11] Juntendo Univ, Sch Med, Dept Internal Med & Rheumatol, Tokyo, Japan

[12] Inst Sci Tokyo, Joint Res Dept Lifelong Immunotherapy, Tokyo, Japan

[13] St Marianna Univ, Sch Med, Dept Internal Med, Div Rheumatol & Allergol, Kawasaki, Japan

[14] Nippon Med Coll Hosp, Dept Pediat, Tokyo, Japan

[15] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Fukuoka, Japan

[16] Kobe City Med Ctr Gen Hosp, Dept Rheumatol, Kobe, Hyogo, Japan

[17] Japanese Red Cross Otsu Hosp, Dept Pediat, Otsu, Japan

[18] Juntendo Univ, Nerima Hosp, Dept Pediat & Adolescent Med, Tokyo, Japan

[19] Tokyo Metropolitan Tama Med Ctr, Dept Rheumat Dis, Tokyo, Japan

[20] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, Kyoto, Japan

来源：

MODERN RHEUMATOLOGY | 2025年

关键词：

Abatacept; comorbidity; Japan; juvenile idiopathic arthritis; National Database; oligoarthritis; polyarthritis; rheumatology; tocilizumab; unmet medical need; DISEASE; CHILDREN;

D O I：

10.1093/mr/roaf032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To identify unmet medical needs (UMNs) of medical practices and investigate the real-world prescribing practices of therapeutic medical treatments and test implementation for patients with juvenile idiopathic arthritis (JIA).Methods The possible UMNs were collected from eight paediatric and eight adult rheumatologists. To verify UMNs, the real-world prescribing practices of therapeutic medical treatments and test implementation for patients with JIA were described using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB).Results Fifty-eight possible UMNs collected from 16 experts and 35 UMNs were investigated using NDB. The highest priority UMNs was the expansion of indications for subcutaneous tocilizumab (TCZ sc) and subcutaneous abatacept- subcutaneous tocilizumab was administered to 12.8% systemic JIA and 5.5% JIA with polyarthritis or oligoarthritis. Comorbidities for systemic JIA and JIA with polyarthritis or oligoarthritis included hypertension (7.1%, 1.3%), osteoporosis (17%, 5.4%), depression (2.3%, 1.3%), diabetes (1.9% systemic JIA), and iritis and/or uveitis (6.5% JIA with polyarthritis or oligoarthritis).Conclusions The highest priority UMNs for JIA was the expansion of indications for abatacept sc and especially subcutaneous tocilizumab. This study reveals the real-world prescribing practices of therapeutic medical treatments and test implementation for patients with JIA in Japan.

引用

页数：7

共 50 条

[21] Seasonality of birth of patients with juvenile idiopathic arthritis
Berkun, Y.
Lewy, H.
Padeh, S.
Laron, Z.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2015, 33 (01) : 122 - 126
[22] A prediction rule for polyarticular extension in oligoarticular-onset juvenile idiopathic arthritis
Schiappapietra, B.
Bava, C.
Rosina, S.
Pistorio, A.
Mongelli, F.
Pederzoli, S.
Verazza, S.
Lanni, S.
Muratore, V
Davi, S.
Dalpra, S.
Varnier, G. C.
Bertamino, M.
Suffia, C.
Bracciolini, G.
Giancane, G.
Consolaro, A.
Ravelli, A.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021, 39 (04) : 913 - 919
[23] Safety of biologic therapies for the treatment of juvenile idiopathic arthritis
Horneff, Gerd
EXPERT OPINION ON DRUG SAFETY, 2015, 14 (07) : 1111 - 1126
[24] Update on the medical treatment of juvenile idiopathic arthritis
Hashkes P.J.
Laxer R.M.
Current Rheumatology Reports, 2006, 8 (6) : 450 - 458
[25] Juvenile Idiopathic Arthritis
Sudhakar, Murugan
Kumar, Sathish
INDIAN JOURNAL OF PEDIATRICS, 2024, 91 (09) : 949 - 958
[26] Juvenile Idiopathic Arthritis
Barut, Kenan
Adrovic, Amra
Sahin, Sezgin
Kasapcopur, Ozgur
BALKAN MEDICAL JOURNAL, 2017, 34 (02) : 90 - 101
[27] Imaging of the hip in juvenile idiopathic arthritis
Shelmerdine, Susan Cheng
Di Paolo, Pier Luigi
de Horatio, Laura Tanturri
Malattia, Clara
Magni-Manzoni, Silvia
Rosendahl, Karen
PEDIATRIC RADIOLOGY, 2018, 48 (06) : 811 - 817
[28] Biologic Therapies in Juvenile Idiopathic Arthritis
Tanatar, Ayse
Ayaz, Nuray Aktay
MEDICAL JOURNAL OF BAKIRKOY, 2023, 19 (03) : 269 - 275
[29] Tocilizumab for the Treatment of Juvenile Idiopathic Arthritis
Decelle, Kendra
Horton, Evan R.
ANNALS OF PHARMACOTHERAPY, 2012, 46 (06) : 822 - 829
[30] Juvenile idiopathic arthritis and oral health
Kobus, Agnieszka
Kierklo, Anna
Sielicka, Danuta
Szajda, Slawomir Dariusz
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2016, 70 : 410 - 419

← 1 2 3 4 5 →