Application of non-coding RNAs in tumors (Review)

被引：0
作者：
Zhang, Zhihan [1 ,2 ]
Mao, Chunyan [1 ,2 ]
Wu, Yi [1 ,2 ]
Wang, Yin [1 ,2 ]
Cong, Hui [1 ,3 ]
机构：
[1] Nantong Univ, Dept Lab Med, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Univ, Med Sch, Dept Clin Med, Nantong 226001, Jiangsu, Peoples R China
[3] Nantong Univ, Affiliated Hosp, Dept Blood Transfus, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2025年 / 31卷 / 06期
关键词：
cancer; long non-coding RNA; microRNA; PIWI-interacting RNAs; transfer RNA-derived small RNA; non-coding RNA; CANCER-CELLS; COLORECTAL-CANCER; GASTRIC-CANCER; PROMOTES PROLIFERATION; DOWN-REGULATION; BREAST-CANCER; LUNG-CANCER; METASTASIS; BIOMARKERS; MIGRATION;
D O I：
10.3892/mmr.2025.13529
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumors are associated with the highest mortality rates worldwide. For more than a decade, research has focused on the genetic involvement of proteins in cancer; however, a complete class of molecular non-coding (nc)RNAs have been discovered in recent years, and these are considered to be associated with cancer. Notably, ncRNAs are highly conserved and multifunctional. These interact with multiple signaling pathways, influencing cell cycle progression and various physiological processes. Therefore, the present review aimed to investigate ncRNA, microRNA, transfer RNA-derived small RNA, PIWI-interacting RNA and long non-coding RNA to further understand the associated generation processes, functional mechanisms and therapeutic roles in tumors. The present review demonstrated the critical role of ncRNAs in tumors, and may provide a novel theoretical basis for the role of ncRNAs as biomarkers or therapeutic tools in the treatment of cancer.
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页数：12
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