Hand grip strength trajectories and the risk of low bone mineral density in 6–7-year-old children: a prospective study

被引：0

作者：

Nuoyun Zhang ^{[1
]}

Chen Liang ^{[1
]}

Wei Du ^{[1
]}

Mingxia Zou ^{[1
]}

Qin Kang ^{[1
]}

Yuhao Xia ^{[1
]}

Yajing Bao ^{[1
]}

Liu Feng ^{[1
]}

Tiancheng Ma ^{[1
]}

Feiyue Li ^{[1
]}

Hongmin Fan ^{[1
]}

机构：

[1] North China University of Science and Technology,Department of Epidemiology, School of Public Health

[2] Hebei Key Laboratory of Occupational Health and Safety for Coal Industry,undefined

[3] Hebei Coordinated Innovation Centre of Occupational Health and Safety,undefined

[4] Tangshan Key Laboratory of Clinical Epidemiology,undefined

来源：

European Journal of Pediatrics | / 184卷 / 6期

关键词：

Hand grip strength; Bone mineral density; Trajectory; Children;

D O I：

10.1007/s00431-025-06204-7

中图分类号：

学科分类号：

摘要：

Hand grip strength (HGS) is significantly correlated with bone mineral density (BMD), but has been assessed at a single time point in the cross-sectional study. The relationship between long-term patterns of HGS and BMD has neglected and not been proven. Therefore, this study aimed to explore the long-term HGS trajectories in 6–7 years old children and the risk of low BMD. This study included 1122 individuals with healthy BMD from Hebei Children and Adolescents aged 6–7 years Cohort Study in 2018 (baseline). HGS was measured 3 times repeatedly in 2018, 2020, and 2022. A cohort-based trajectory model was used to identify 4-year HGS developmental trajectories in the total participants, while HGS developmental trajectories were identified separately in subgroup analyses for sex, body mass index (BMI), and height. Cox proportional hazards models were used to test the association between HGS trajectories and low BMD. Three trajectories of HGS in the 1122 participants from 2018 to 2022 were identified and labeled as low-rate growth (blue-group1) (530, 47.2%), moderately-rate growth (red-group2) (518, 46.2%), and high-rate growth (green-group3) (74, 6.6%) respectively. Only 102 cases of low BMD were identified, the risk of low BMD was 9.1%. Participants in the low-rate growth group had a higher incidence of low BMD compared with the high-rate growth group [12.8% vs 2.7%, hazard ratio (HR): 5.74; 95% confidence interval (CI): 1.31, 25.15; P = 0.02]. Besides, the risk of low BMD decreased with the HGS changing trajectory increased in those two models (Ptrend < 0.05). And the same dose–response relationship was demonstrated in subgroup analyses of sex (boys, girls); however, in subgroup analyses for body mass index (normal, overweight/obese) and height (≤ median, > median), this relationship was only observed in those with normal BMI and height > P50.

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