Lanthanide-Doped Upconversion Nanoparticles for Single-Particle Imaging

被引：0
作者：
Ling, Huan [1 ,2 ]
Zhang, Wenrui [1 ,2 ]
Zhang, Yunxiang [1 ,2 ]
Shen, Jie [3 ]
Liu, Qian [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China
[2] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200438, Peoples R China
[3] Peking Univ, Sch Mat Sci & Engn, Beijing 100871, Peoples R China
来源：
CHEMBIOCHEM | 2025年 / 26卷 / 11期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
lanthanides; nanoparticles; single-particle imaging; surface modifications; upconversion; UPCONVERTING NANOPARTICLES; MOLECULE FLUORESCENCE; LUMINESCENCE; SURFACE; TRACKING; EMISSION; BRIGHT; NANOCHEMISTRY; FLUOROPHORES; ENHANCEMENT;
D O I：
10.1002/cbic.202400942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lanthanide-doped upconversion nanoparticles (UCNPs) have recently demonstrated great promise in single-particle imaging (SPI) due to their exceptional photostability and minimal background fluorescence. However, their limited brightness has posed a significant barrier to wider adoption in SPI applications. This review highlights recent advances in applying UCNPs for SPI, focusing on strategies to enhance their brightness and reduce quenching effects in aqueous environments. Additionally, it summarizes the latest progress in using UCNPs for single-particle tracking and super-resolution imaging, underscoring their potential in biomedical research. Finally, the review outlines current challenges and future directions in this field.
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页数：13
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