Therapy of early breast cancer: current status and perspectives

被引：1

作者：

Tauber, Nikolas ^{[1
]}

Amann, Niklas ^{[2
]}

Dannehl, Dominik ^{[3
]}

Deutsch, Thomas M. ^{[4
]}

Dimpfl, Moritz ^{[5
]}

Fasching, Peter ^{[2
]}

Hartkopf, Andreas ^{[3
]}

Heublein, Sabine ^{[6
]}

Hilmer, Lisbeth ^{[1
]}

Hoerner, Manuel ^{[2
]}

Krawczyk, Natalia ^{[7
]}

Krueckel, Annika ^{[2
]}

Krug, David ^{[8
]}

Marme, Frederik ^{[5
]}

Michel, Laura L. ^{[9
,10
]}

Reinisch, Mattea ^{[5
]}

Rody, Achim ^{[1
]}

Schaeffler, Henning ^{[6
]}

Schneeweiss, Andreas ^{[9
,10
,11
]}

Utz, David ^{[12
]}

Veselinovic, Kristina ^{[6
]}

Banys-Paluchowski, Maggie ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Campus Luebeck, Lubeck, Germany

[2] Friedrich Alexander Univ Erlangen Nuremberg FAU, Erlangen Univ Hosp, Comprehens Canc Ctr Erlangen EMN CCC ER EMN, Dept Obstet & Gynecol, Erlangen, Germany

[3] Univ Hosp Tuebingen, Dept Obstet & Gynecol, D-72016 Tubingen, Germany

[4] Univ Hosp Heidelberg, Dept Obstet & Gynecol, Heidelberg, Germany

[5] Heidelberg Univ, Univ Med Ctr Mannheim, Med Fac Mannheim, Dept Obstet & Gynecol, Mannheim, Germany

[6] Univ Hosp Ulm, Dept Obstet & Gynecol, D-89075 Ulm, Germany

[7] Univ Hosp Duesseldorf, Dept Obstet & Gynecol, D-40225 Dusseldorf, Germany

[8] Univ Med Ctr Hamburg Eppendorf, Dept Radiotherapy & Radiat Oncol, Hamburg, Germany

[9] Univ Hosp, Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany

[10] German Canc Res Ctr Heidelberg, D-69120 Heidelberg, Germany

[11] German Canc Res Ctr, D-69120 Heidelberg, Germany

[12] Univ Hosp Tuebingen, Dept Internal Med Med Oncol & Pneumol 8, D-72016 Tubingen, Germany

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2025年

关键词：

Early breast cancer; Future perspectives; Surgical de-escalation; HER2-positive; Triple-negative; Hormone-receptor positive; OPEN-LABEL; SENTINEL-NODE; CONSERVING SURGERY; ENDOCRINE THERAPY; TRASTUZUMAB; MULTICENTER; SURVIVAL; CHEMOTHERAPY; RADIOTHERAPY; RECURRENCE;

D O I：

10.1007/s00404-025-08028-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Medical advancements in breast cancer are truly remarkable. Especially in recent years, numerous new therapeutics have been approved and surgical strategies have been de-escalated for specific patient groups. In the therapeutic setting, CDK4/6 inhibitors as oral maintenance therapy in early breast cancer and immune checkpoint inhibitors (Pembrolizumab) for triple-negative breast cancer (BC) are noteworthy. In the surgical field, prospective randomized controlled trials have currently explored the possibility to deescalate axillary surgery by omitting sentinel lymph node excision (INSEMA, SOUND). As a result, there have been significant improvements in prognosis and a reduction in surgical morbidity for patients. Many exciting trials are underway, and it remains to be seen whether antibody-drug conjugates beyond trastuzumab emtansine, will find their way into the treatment lines for early-stage BC. Furthermore, the integration of artificial intelligence in both diagnostics and treatment recommendation evaluation is a promising area with great potential.

引用

页数：18

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