Synthesis and Anti-Inflammatory Activity of Spiropyrimido[4,5-d]pyrimidine Derivatives

被引：0

作者：

Maalej, Emna ^{[1
]}

Ziri, Olfa Kallech ^{[2
]}

Ayadi, Wiem ^{[2
]}

Bernard, Paul J. ^{[3
]}

Lopez-Munoz, Francisco ^{[4
,5
,6
]}

Marco-Contelles, J. ^{[7
]}

Chabchoub, Fakher ^{[8
]}

Refouvelet, Bernard ^{[3
]}

Ismaili, Lhassane ^{[3
]}

机构：

[1] Ctr Biotechnol Sfax, Lab Mol & Cellular Screening Proc, POB 1177, Sfax 3018, Tunisia

[2] Inst Natl Rech & Anal Physico Chim, Lab Subst Naturelles LR10INRAP02, Ariana 2020, Tunisia

[3] Univ Franche Comte, INSERM, UMR 1322, LINC, F-25000 Besancon, France

[4] Univ Camilo Jose Cela, HM Hosp, Fac Hlth Sci, Madrid 28692, Spain

[5] HM Hosp, Hlth Res Inst, Madrid 28015, Spain

[6] Hosp 12 Octubre Res Inst, Neuropsychopharmacol Unit, Madrid 28041, Spain

[7] Inst Gen Organ Chem CSIC, C Juan De La Cierva 3, Madrid 28006, Spain

[8] Univ Sfax, Fac Sci Sfax, Lab Appl Chem Heterocycles Lipids & Polymers, BP 802, Sfax 3000, Tunisia

来源：

CHEMISTRYSELECT | 2025年 / 10卷 / 15期

关键词：

Anti-inflammatory agents; Biological activity; Friedlander reaction; Spiropyrimido[4,5-d] pyrimidines; Synthesis; PHARMACOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; INHIBITORS; DISCOVERY; CANCER; AGENTS;

D O I：

10.1002/slct.202500270

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we describe the high yielding synthesis of spiropyrimido[4,5-d]pyrimidines by Friedl & auml;nder-type reaction of substituted 4-aminopyrimidine-5-carbonitriles with cyclohexanone, using sodium ethoxide as catalyst. The biological activity of the new compounds as anti-inflammatory agents was evaluated and to predict their pharmacological properties a comprehensive in silico analysis was conducted. Among the tested compound, three compounds exhibited a potent lipoxygenase inhibitory activity comparing very well with reference octyl gallate.

引用

页数：5

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