A cell atlas of human endometrium reveals key molecular and cellular alterations in PCOS

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10.1038/s41591-025-03672-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A human cellular and molecular atlas of the proliferative endometrium in polycystic ovary syndrome (PCOS) was generated via single-nucleus RNA sequencing and spatial transcriptomics. This study reveals PCOS-specific alterations in cellular composition and gene expression, and identifies potential therapeutic targets. These findings could advance treatments for PCOS-related endometrial dysfunction and associated health challenges.
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页码:1763 / 1764
页数:2
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