The role of mesenchymal stem cell-derived exosomes in asthma (Review)

被引：0
作者：
Lv, Kaiying [1 ]
Gao, Jiawei [1 ]
Yang, Liuxin [1 ]
Yuan, Xingxing [1 ,2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Dept Grad Studies, Harbin 150040, Heilongjiang, Peoples R China
[2] Heilongjiang Acad Tradit Chinese Med, Dept Gastroenterol, 24 Heping Rd, Harbin 150006, Heilongjiang, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2025年 / 31卷 / 06期
基金：
中国国家自然科学基金;
关键词：
asthma; mesenchymal stem cells; exosome; microRNA; therapy; EXTRACELLULAR VESICLES; THERAPIES; SECRETION; RISK;
D O I：
10.3892/mmr.2025.13531
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Asthma is a chronic respiratory disorder characterized by persistent inflammation, airway hyper-responsiveness and remodeling, leading to notable morbidity and decreased quality of life for patients. Mesenchymal stem cells (MSCs) have potential in regenerative medicine due to their potent immunomodulatory properties and anti-inflammatory effects. The therapeutic benefits of MSCs are largely mediated by secreted exosomes that facilitate intercellular communication by transferring bioactive molecules, including proteins, lipids and microRNAs. The present review explores the therapeutic potential of MSC-derived exosomes in asthma, highlighting their ability to modulate key pathological mechanisms underlying the disease.
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