Mavacamten Inhibits the Effect of the N-Terminal Fragment of Cardiac Myosin-Binding Protein C with the L352P Mutation on the Actin–Myosin Interaction at Low Calcium Concentrations

被引：0

作者：

Anastasia M. Kochurova ^{[1
]}

Evgenia A. Beldiia ^{[1
]}

Julia Y. Antonets ^{[1
]}

Victoria V. Nefedova ^{[2
]}

Natalia S. Ryabkova ^{[3
]}

Ivan A. Katrukha ^{[4
]}

Sergey Y. Bershitsky ^{[3
]}

Alexander M. Matyushenko ^{[4
]}

Galina V. Kopylova ^{[1
]}

Daniil V. Shchepkin ^{[2
]}

机构：

[1] Institute of Immunology and Physiology,Department of Biochemistry, Faculty of Biology

[2] Russian Academy of Sciences,undefined

[3] Research Center of Biotechnology,undefined

[4] Russian Academy of Sciences,undefined

[5] Lomonosov Moscow State University,undefined

[6] Hytest Ltd.,undefined

来源：

Biochemistry (Moscow) | 2025年 / 90卷 / 3期

关键词：

actin–myosin interaction; hypertrophic cardiomyopathy; mavacamten; calcium regulation; motility assay; cardiac myosin-binding protein C;

D O I：

10.1134/S0006297924604131

中图分类号：

学科分类号：

摘要：

引用

页码：389 / 399

页数：10

共 14 条

[1] N-Terminal Fragment of Cardiac Myosin Binding Protein-C Increases the Duration of Actin—Myosin Interaction
S. R. Nabiev
A. M. Kochurova
L. V. Nikitina
E. A. Beldiia
A. M. Matyushenko
D. S. Yampolskaya
S. Yu. Bershitsky
G. V. Kopylova
D. V. Shchepkin
Bulletin of Experimental Biology and Medicine, 2024, 176 : 324 - 327
[2] N-Terminal Fragment of Cardiac Myosin Binding Protein-C Increases the Duration of Actin-Myosin Interaction
Nabiev, S. R.
Kochurova, A. M.
Nikitina, L. V.
Beldiia, E. A.
Matyushenko, A. M.
Yampolskaya, D. S.
Bershitsky, S. Yu.
Kopylova, G. V.
Shchepkin, D. V.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2024, 176 (03) : 305 - 309
[3] N-terminal extension in cardiac myosin-binding protein C regulates myofilament binding
Bunch, Thomas A.
Lepak, Victoria C.
Kanassatega, Rhye-Samuel
Colson, Brett A.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2018, 125 : 140 - 148
[4] The Effect of Cardiac Myosin-Binding Protein C on Calcium Regulation of the Actin–Myosin Interaction Depends on Myosin Light Chain Isoforms
Nabiev S.R.
Kopylova G.V.
Shchepkin D.V.
Biophysics, 2019, 64 (5) : 690 - 693
[5] Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations
Wong, Fiona L.
Bunch, Thomas A.
Lepak, Victoria C.
Steedman, Allison L.
Colson, Brett A.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2024, 186 : 125 - 137
[6] Effect of Cardiac Myosin-Binding Protein C on Tropomyosin Regulation of Actin—Myosin Interaction Using In Vitro Motility Assay
D. V. Shchepkin
G. V. Kopylova
L. V. Nikitina
Bulletin of Experimental Biology and Medicine, 2016, 162 : 45 - 47
[7] Effect of Cardiac Myosin-Binding Protein C on Tropomyosin Regulation of Actin-Myosin Interaction Using In Vitro Motility Assay
Shchepkin, D. V.
Kopylova, G. V.
Nikitina, L. V.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 162 (01) : 45 - 47
[8] N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles
Anastasia M. Kochurova
Evgenia A. Beldiia
Victoria V. Nefedova
Natalia S. Ryabkova
Daria S. Yampolskaya
Alexander M. Matyushenko
Sergey Y. Bershitsky
Galina V. Kopylova
Daniil V. Shchepkin
Biochemistry (Moscow), 2024, 89 : 116 - 129
[9] N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles
Kochurova, Anastasia M.
Beldiia, Evgenia A.
Nefedova, Victoria V.
Ryabkova, Natalia S.
Yampolskaya, Daria S.
Matyushenko, Alexander M.
Bershitsky, Sergey Y.
Kopylova, Galina V.
Shchepkin, Daniil V.
BIOCHEMISTRY-MOSCOW, 2024, 89 (01) : 116 - 129
[10] N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro
Lipps, Christoph
Nguyen, Jenine H.
Pyttel, Lukas
Lynch, Thomas L.
Liebetrau, Christoph
Aleshcheva, Ganna
Voss, Sandra
Doerr, Oliver
Nef, Holger M.
Moellmann, Helge
Hamm, Christian W.
Sadayappan, Sakthivel
Troidl, Christian
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 99 : 47 - 56

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