Role of Ion Channels in Alzheimer's Disease Pathophysiology

被引：0

作者：

Bhoi, Ranjit ^{[1
,2
]}

Mitra, Tuhina ^{[1
,2
]}

Tejaswi, Kallam ^{[1
,2
]}

Manoj, Vaishnav ^{[1
,2
]}

Ghatak, Swagata ^{[1
,2
]}

机构：

[1] Natl Inst Sci Educ & Res NISER, Sch Biol Sci, Bhubaneswar 752050, India

[2] Homi Bhabha Natl Inst, Training Sch Complex, Mumbai 400094, India

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2025年 / 258卷 / 03期

关键词：

Ion channels; Alzheimer's disease; Hyperexcitability; RECTIFYING POTASSIUM CHANNELS; CENTRAL NEUROPATHIC PAIN; LONG-TERM POTENTIATION; AMYLOID-BETA; CALCIUM-CHANNELS; NMDA RECEPTOR; AMPA RECEPTOR; MOUSE MODEL; HIPPOCAMPAL-NEURONS; MULTIPLE-SCLEROSIS;

D O I：

10.1007/s00232-025-00341-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ion channels play an integral role in the normal functioning of the brain. They regulate neuronal electrical properties like synaptic activity, generation of action potentials, maintenance of resting membrane potential and neuronal plasticity, and modulate the physiology of non-neuronal cells like astrocytes and microglia. Dysregulation of ionic homeostasis and channelopathies are associated with various neurological disorders, including Alzheimer's disease (AD). Several families of ion channels are associated with AD pathophysiology and progression. In this review, we outline the current research centered around ion channel dysregulation during AD and discuss briefly the possibility of using ion channels as therapeutic targets.

引用

页码：187 / 212

页数：26

共 224 条

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