Interplay of Neuroinflammation and Epilepsy in Glioblastoma Multiforme: Mechanisms and Therapeutic Implications

被引：0

作者：

Fereshteh Golab ^{[1
]}

Pooya Hajimirzaei ^{[2
]}

Sam Zarbakhsh ^{[3
]}

Samira Zolfaghari ^{[4
]}

Parisa Hayat ^{[5
]}

Mohammad Taghi Joghataei ^{[1
]}

Fatemeh Bakhtiarzadeh ^{[1
]}

Nooshin Ahmadirad ^{[6
]}

机构：

[1] Iran University of Medical Sciences,Cellular and Molecular Research Center

[2] University of Medical Sciences,Department of Radiation Sciences, Allied Medicine Faculty, Iranaq

[3] Semnan University of Medical Sciences,Nervous System Stem Cells Research Center

[4] Semnan University of Medical Sciences,Department of Anatomy, Faculty of Medicine

[5] Iran University of Medica Sciences,Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine

[6] Rutgers University,Department of Neurosurgery, Robert Wood Johnson Medical School

来源：

Journal of Molecular Neuroscience | / 75卷 / 2期

关键词：

GBM; Seizure; Neuroinflammation; BBB dysfunction; Ion homeostasis; Tumor-associated macrophages;

D O I：

10.1007/s12031-025-02335-6

中图分类号：

学科分类号：

摘要：

Glioblastoma multiforme (GBM) is the most aggressive form of primary brain cancer in adults and is characterized by poor prognosis and a high incidence of seizures due to tumor-induced alterations in cerebral physiology. This review explores the complex interactions between GBM-induced neuroinflammation and epilepsy, emphasizing the mechanisms of epileptogenesis influenced by blood–brain barrier dysfunction, ion homeostasis, and neurotransmitter dynamics. We discuss the roles of pro-inflammatory mediators such as interleukin-1β and tumor necrosis factor-alpha in exacerbating excitatory synaptic activity while inhibiting inhibitory signaling, thus creating a milieu conducive to seizure activity. Furthermore, we evaluated the efficacy of current anti-seizure medications and emerging therapeutic strategies, including the reprogramming of tumor-associated macrophages, in managing GBM-related epilepsy and tumor growth. This study aimed to elucidate the critical pathways connecting GBM and epilepsy, thereby advancing our understanding of potential interventional approaches to improve patient outcomes.

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