Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study

被引：0

作者：

Sawane, Kento ^{[1
]}

Takahashi, Ippei ^{[2
]}

Ishikuro, Mami ^{[2
,3
]}

Takumi, Hiroko ^{[1
]}

Orui, Masatsugu ^{[2
,3
]}

Noda, Aoi ^{[2
,3
,4
]}

Shinoda, Genki ^{[2
,3
]}

Ohseto, Hisashi ^{[2
]}

Onuma, Tomomi ^{[5
]}

Ueno, Fumihiko ^{[3
]}

Murakami, Keiko ^{[3
]}

Higuchi, Naoko ^{[1
]}

Furuyashiki, Takashi ^{[1
]}

Nakamura, Tomohiro ^{[6
,7
]}

Koshiba, Seizo ^{[5
,8
]}

Ohneda, Kinuko ^{[9
]}

Kumada, Kazuki ^{[8
,9
]}

Ogishima, Soichi ^{[6
,8
]}

Hozawa, Atsushi ^{[3
,10
,11
]}

Sugawara, Junichi ^{[12
]}

Kuriyama, Shinichi ^{[2
,3
,13
]}

Obara, Taku ^{[2
,3
,4
]}

机构：

[1] Ezaki Glico Co Ltd, Osaka, Japan

[2] Tohoku Univ, Grad Sch Med, Div Mol Epidemiol, Sendai, Japan

[3] Tohoku Univ, Tohoku Med Megabank Org, Dept Prevent Med & Epidemiol, Sendai, Japan

[4] Tohoku Univ Hosp, Dept Pharmaceut Sci, Sendai, Japan

[5] Tohoku Univ, Tohoku Med Megabank Org, Dept Integrat Genom, Sendai, Japan

[6] Tohoku Univ, Dept Hlth Record Informat, Tohoku Med Megabank Org, Sendai, Japan

[7] Kyoto Womens Univ, Fac Data Sci, Kyoto, Japan

[8] Tohoku Univ, Adv Res Ctr Innovat Next Generat Med, Sendai, Japan

[9] Tohoku Univ, Tohoku Med Megabank Org, Dept Biobank, Sendai, Japan

[10] Tohoku Univ, Sch Publ Hlth, Grad Sch Med, Div Epidemiol, Sendai, Miyagi, Japan

[11] Tohoku Univ, Grad Sch Med, Div Personalized Prevent & Epidemiol, Sendai, Japan

[12] Suzuki Mem Hosp, Iwanuma, Miyagi, Japan

[13] Tohoku Univ, Int Res Inst Disaster Sci, Div Disaster Publ Hlth, Sendai, Japan

来源：

NUTRITION | 2025年 / 135卷

关键词：

Breast milk; Child growth; Adiposity rebound; Obesity; Lipid; Metabolic disorder; CHOLESTEROL-SYNTHESIS; CHILDHOOD; RISK; INFANTS; FORMULA; PROFILE; ESTER;

D O I：

10.1016/j.nut.2025.112739

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objectives: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk are important in child growth, information is limited regarding which lipids are involved in AR. The object of this study was to explore the association between breast milk lipids and AR status in children. Methods: We designed a case-control study of 184 mother-child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Breast milk was collected 1 month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children. Results: We detected 667 lipid molecules in 12 lipid classes in breast milk. Partial least square-discriminant analysis revealed the association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that in pairs with exclusive breastfeeding at 1 month postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) was positively associated with early AR, and ChE (odds ratio 0.55 [95% confidence interval, 0.36-0.86]) was negatively associated. Conclusions: Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood. (c) 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

引用

页数：8

共 55 条

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