Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes

被引:0
作者
Inger Johansson [1 ]
Yuchen Lu [1 ]
Yitian Zhou [1 ]
Kristi Krebs [2 ]
Martina Akcan [3 ]
Lili Milani [1 ]
Magnus Ingelman-Sundberg [3 ]
机构
[1] Karolinska Institutet,Department of Physiology and Pharmacology
[2] Karolinska Institutet and Karolinska University Hospital,Center for Molecular Medicine
[3] University of Tartu,Estonian Genome Centre, Institute of Genomics
关键词
Pharmacogenomics; Clopidogrel; Omeprazole; Antidepressants; Antipsychotics;
D O I
10.1186/s40246-025-00765-2
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study
    Richards-Belle, Alvin
    Austin-Zimmerman, Isabelle
    Wang, Baihan
    Zartaloudi, Eirini
    Cotic, Marius
    Gracie, Caitlin
    Saadullah Khani, Noushin
    Wannasuphoprasit, Yanisa
    Wronska, Marta
    Dawda, Yogita
    Osborn, David P. J.
    Bramon, Elvira
    JOURNAL OF PSYCHOPHARMACOLOGY, 2023, 37 (04) : 396 - 407
  • [22] The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients
    Baumann, Pierre
    Eap, Chin B.
    Gastpar, Markus
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 126 (05) : 444 - 447
  • [23] Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups
    Waade, Ragnhild Birkeland
    Hermann, Monica
    Moe, Hanne Lewis
    Molden, Espen
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (08) : 933 - 940
  • [24] Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups
    Ragnhild Birkeland Waade
    Monica Hermann
    Hanne Lewis Moe
    Espen Molden
    European Journal of Clinical Pharmacology, 2014, 70 : 933 - 940
  • [25] Rapid genotyping of CYP2D6, CYP2C19 and TPMT polymorphisms by primer extension reaction in a dipstick format
    Ioannis K. Litos
    Evaggelia Emmanouilidou
    Kyriaki M. Glynou
    Eleftheria Laios
    Penelope C. Ioannou
    Theodore K. Christopoulos
    Marilena Kampa
    Elias Castanas
    Achille Gravanis
    Analytical and Bioanalytical Chemistry, 2007, 389 : 1849 - 1857
  • [26] Novel CYP2D6 and CYP2C19 variants identified in a patient with adverse reactions towards venlafaxine monotherapy and dual therapy with nortriptyline and fluoxetine
    Chua, Eng Wee
    Foulds, James
    Miller, Allison L.
    Kennedy, Martin A.
    PHARMACOGENETICS AND GENOMICS, 2013, 23 (09) : 494 - 497
  • [27] How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping
    Verbeurgt, Paul
    Mamiya, Tyler
    Oesterheld, Jessica
    PHARMACOGENOMICS, 2014, 15 (05) : 655 - 665
  • [28] Serotonin syndrome following drug-drug interactions and CYP2D6 and CYP2C19 genetic polymorphisms in an HIV-infected patient
    Lorenzini, Kuntheavy I.
    Calmy, Alexandra
    Ambrosioni, Juan
    Assouline, Benjamin
    Daali, Youssef
    Fathi, Marc
    Rebsamen, Michela
    Desmeules, Jules
    Samer, Caroline F.
    AIDS, 2012, 26 (18) : 2417 - 2418
  • [29] Estimating the Potential Impact of CYP2C19 and CYP2D6 Genetic Testing on Protocol-Based Care for Depression in Canada and United States
    Fan, Mikayla
    Bousman, Chad
    NEUROPSYCHOPHARMACOLOGY, 2019, 44 (SUPPL 1) : 312 - 313
  • [30] Association of CYP2C19*2 and*17 genetic variants with hypertension in Pakistani population
    Riaz, Sana
    Mansoor, Atika
    Siddiqi, Saima
    Tareen, Muhammad Usman
    Rubab, Sana
    Batool, Ayesha
    Anwarullah
    Sultan, Aneesa
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2019, 18 (04) : 851 - 855