Should the load-to-fracture test for CAD/CAM monolithic molar crowns be standardized and how? A systematic review and finite element analysis

The load-to-fracture test is widely used to evaluate crowns made of new CAD/CAM materials, even though its validity in predicting clinical performances is often questioned. Despite its limitations, the test is useful in assessing the load-bearing capacity of crowns subjected to accidental overloads and setting up step-stress regimes for fatigue testing. This study combined a systematic review (SR) and finite element analysis (FEA) to assess whether the test should be standardized and how. The SR evaluated load-to-fracture studies of monolithic CAD/CAM molar crowns published in Q1 and Q2 journals. Findings from 85 studies highlighted the lack of standardization in test methods, particularly regarding loading head type and die material. This variability led to a wide dispersion of fracture load results, limiting the utility of the load-to-fracture test. The FEA evaluated the influence of loading head type and die material on tensile stress distribution in lithium disilicate (LD) and polymer-infiltrated ceramic network (PICN) crowns. Eight in vitro conditions were simulated, varying the loading head (4 mm and 10 mm spheres, inverse V-shaped device, opposing teeth) and die material (stiff, E = 207 GPa; non-stiff, E = 13 GPa). The FEA confirmed that the stress distribution and peak tensile stress in LD and PICN crowns depend significantly on these factors as well as the crown material properties, with the peak stress variation from LD to PICN ranging from-4 % to 237 %. Using larger-diameter spheres with a die material approximating dentin in stiffness resulted in stress distributions more representative of clinical conditions.