Synthesis and Sympatholytic and Adrenomimetic Activities of Amino Amides and Amino Esters Based on 1-(1,3-Benzodioxol-5-yl)cyclopentane- and 4-(1,3-Benzodioxol-5-yl)tetrahydro-2H-pyran-4-carboxylic Acids

被引：0

作者：

Margaryan, R. E. ^{[1
]}

Stepanyan, G. V. ^{[1
]}

Aghekyan, A. A. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Arutyunyan, S. A. ^{[1
]}

Tsatinyan, A. S. ^{[1
]}

Grigoryan, M. S. ^{[1
]}

Mkryan, G. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 61卷 / 03期

关键词：

1,3-benzodioxole; cyclopentane; tetrahydropyran; dialkylaminoalkylamines; aminoalkylalkanols; carboxamides; carboxylates; AGONISTS;

D O I：

10.1134/S107042802560010X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of 2-(1,3-benzodioxol-5-yl)acetonitrile with 1,4-dibromobuthane and 2,2 '-bis(2-chloroethyl) ether gave 1-(1,3-benzodioxol-5-yl)cyclopentane- and 4-(1,3-benzodioxol-5-yl)tetrahydro-2H-pyran-4-carbonitriles which were hydrolyzed in alkaline medium to the corresponding carboxylic acids, and the latter were converted to acid chlorides. 1-(1,3-Benzodioxol-5-yl)cyclopentane- and 4-(1,3-benzodioxol-5-yl)tetrahydro-2H-pyran-4-carbonyl chlorides reacted with N,N-dialkylaminoalkyl- and hetarylalkylamines, as well as with N,N-dialkylaminoalkanols and hetarylalkanols, to afford the target (1,3-benzodioxol-5-yl)cyclopentane(tetrahydropyran)carboxamides and (1,3-benzodioxol-5-yl)cyclopentane(tetrahydropyran)carboxylates. The synthesized compounds were evaluated for their effects on the cardiovascular system and blood hemodynamics.

引用

页码：403 / 411

页数：9

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