Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus Aspergillus sp. NF666

被引：0
作者：
Jiao, Fangwen [1 ,2 ,3 ]
Liu, Tianyu [1 ]
Wang, Kaiwei [1 ]
Li, Shuai [1 ]
Jiao, Ruihua [4 ]
Lin, Wei [1 ]
机构：
[1] Nanjing Univ Chinese Med, Sch Med, Dept Pathogen Biol, Nanjing 210023, Peoples R China
[2] Jiangsu Key Lab Med Subst & Utilizat Fresh Chinese, Nanjing 210023, Peoples R China
[3] State Key Lab Dao Di Herbs, Beijing 100700, Peoples R China
[4] Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
来源：
MOLECULES | 2025年 / 30卷 / 07期
基金：
中国国家自然科学基金;
关键词：
tetramic acid; zopfiellamides; marine fungus; Aspergillus sp; structure elucidation; antibacterial activity; biosynthesis; PROTEIN-PROTEIN INTERACTION; NATURAL-PRODUCTS; ELUCIDATION; INHIBITORS; JBIR-22;
D O I：
10.3390/molecules30071502
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (1) and D (2) were isolated from the marine-derived fungus Aspergillus sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (1 and 2) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 mu Mu. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (2) in this work.
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页数：8
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