Rectal stenosis after immunotherapy in a mismatch repair deficient rectal cancer. Case report and review of literature

被引：0

作者：

Buettner, Marcel ^{[1
]}

Schempf, Ulrike ^{[2
]}

Bachmann, Robert ^{[3
]}

Hoffmann, Ruediger ^{[4
]}

Schroeder, Christopher ^{[5
]}

Mattern, Sven ^{[6
,7
]}

Singer, Stephan ^{[6
,7
]}

Steinle, Marc ^{[1
]}

Niyazi, Maximilian ^{[1
]}

Bitzer, Michael ^{[2
]}

Gani, Cihan ^{[1
]}

机构：

[1] Univ Hosp Tubingen, Dept Radiat Oncol, Tubingen, Germany

[2] Univ Hosp Tuebingen, Dept Internal Med 1, D-72076 Tubingen, Germany

[3] Eberhard Karl Univ, Univ Hosp Tubingen, Gen Visceral & Transplantat Surg, D-72076 Tubingen, Germany

[4] Univ Hosp Tubingen, Dept Diagnost & Intervent Radiol, Tubingen, Germany

[5] Univ Tubingen, Inst Med Genet & Appl Genom, Tubingen, Germany

[6] Univ Hosp, Dept Pathol & Neuropathol, Tubingen, Germany

[7] Comprehens Canc Ctr Tubingen, Tubingen, Germany

来源：

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | 2025年 / 53卷

关键词：

Rectal cancer; Immunotherapy; Stenosis; Colorectal cancer;

D O I：

10.1016/j.ctro.2025.100953

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a 57-year-old male patient who presented with a circumferential cT3 cN1 rectal adenocarcinoma in the mid rectum. The tumor was found to be mismatch repair deficient/microsatellite instable (dMMR/MSI). Instead of multimodality treatment with chemoradiotherapy immunotherapy with Dostarlimab was initiated. Treatment was well-tolerated in general and endoscopy and MRI showed early signs of treatment response. Despite this, the patient developed intestinal obstruction due to scarring that required repeat balloon dilations. In contrast to other oncological treatments, obstructions may worsen during immunotherapy in dMMR rectal cancers. This information has to be considered when patients are consulted regarding the optimal treatment after disease.

引用

页数：3

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