Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study

被引：0

作者：

Fohner, Alison E. ^{[1
,2
,3
]}

Sitlani, Colleen M. ^{[3
]}

Jayadev, Suman ^{[4
]}

Bis, Joshua C. ^{[3
]}

Trittschuh, Emily H. ^{[5
,6
]}

Lopez, Oscar L. ^{[7
]}

Tracy, Russel P. ^{[8
,9
]}

Psaty, Bruce M. ^{[1
,3
,10
]}

Longstreth Jr, W. T. ^{[1
,4
]}

Seshadri, Sudha ^{[11
]}

机构：

[1] Univ Washington, Dept Epidemiol, Box 351619, Seattle, WA 98195 USA

[2] Univ Washington, Inst Publ Hlth Genet, Seattle, WA USA

[3] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA

[4] Univ Washington, Dept Neurol, Seattle, WA USA

[5] Univ Washington, Dept Psychiat & Behav Med, Seattle, WA USA

[6] Geriatr Res Educ & Clin Ctr GRECC, Seattle, WA USA

[7] Univ Pittsburgh, Dept Neurol & Psychiat, Pittsburgh, PA USA

[8] Univ Vermont, Larner Coll Med, Dept Pathol & Lab Med, Burlington, VT USA

[9] Univ Vermont, Larner Coll Med, Dept Biochem, Burlington, VT USA

[10] Univ Washington, Dept Syst & Populat Hlth, Seattle, WA USA

[11] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Neurol, San Antonio, TX USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2025年 / 105卷 / 04期

关键词：

Alzheimer's disease; brain pathology; cognitive decline; neurodegeneration; ALZHEIMERS-DISEASE; DEMENTIA; PREDICTORS; PATHOLOGY; MANIFESTATIONS; PREVALENCE;

D O I：

10.1177/13872877251334820

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.

引用

页码：1275 / 1281

页数：7

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