Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution

被引：4

作者：

Loft, Anne ^{[1
]}

Emont, Margo P. ^{[2
]}

Weinstock, Ada ^{[3
]}

Divoux, Adeline ^{[4
]}

Ghosh, Adhideb ^{[5
]}

Wagner, Allon ^{[6
,7
,8
]}

Hertzel, Ann V. ^{[9
]}

Maniyadath, Babukrishna ^{[1
]}

Deplancke, Bart ^{[10
]}

Liu, Boxiang ^{[11
,12
,13
,14
,15
,16
]}

Scheele, Camilla ^{[17
]}

Lumeng, Carey ^{[18
]}

Ding, Changhai ^{[19
,20
]}

Ma, Chenkai ^{[21
]}

Wolfrum, Christian ^{[5
]}

Strieder-Barboza, Clarissa ^{[22
,23
]}

Li, Congru ^{[24
]}

Truong, Danh D. ^{[25
]}

Bernlohr, David A. ^{[9
]}

Stener-Victorin, Elisabet ^{[24
]}

Kershaw, Erin E. ^{[26
]}

Yeger-Lotem, Esti ^{[27
]}

Shamsi, Farnaz ^{[28
,29
,30
]}

Hui, Hannah X. ^{[31
]}

Camara, Henrique ^{[32
]}

Zhong, Jiawei ^{[33
]}

Kalucka, Joanna ^{[34
,35
]}

Ludwig, Joseph A. ^{[25
]}

Semon, Julie A. ^{[36
]}

Jalkanen, Jutta ^{[33
]}

Whytock, Katie L. ^{[4
]}

Dumont, Kyle D. ^{[37
]}

Sparks, Lauren M. ^{[4
]}

Muir, Lindsey A. ^{[38
]}

Fang, Lingzhao ^{[39
]}

Massier, Lucas ^{[40
,41
]}

Saraiva, Luis R. ^{[42
,43
,44
]}

Beyer, Marc D. ^{[45
,46
,47
,48
]}

Jeschke, Marc G. ^{[49
,50
]}

Mori, Marcelo A. ^{[51
,52
]}

Boroni, Mariana ^{[53
]}

Walsh, Martin J. ^{[54
]}

Patti, Mary-Elizabeth ^{[32
]}

Lynes, Matthew D. ^{[55
]}

Blueher, Matthias ^{[40
,41
,56
]}

Ryden, Mikael ^{[57
,58
]}

Hamda, Natnael ^{[59
]}

Solimini, Nicole L. ^{[60
]}

Mejhert, Niklas ^{[57
,58
]}

Gao, Peng ^{[61
]}

机构：

[1] Univ Southern Denmark SDU, Ctr Funct Genom & Tissue Plast ATLAS, Dept Biochem & Mol Biol, Odense, Denmark

[2] Univ Chicago, Sect Endocrinol Diabet & Metab, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Med, Sect Genet Med, Chicago, IL USA

[4] AdventHlth, Translat Res Inst, Orlando, FL USA

[5] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Dept Hlth Sci & Technol, Schwerzenbach, Switzerland

[6] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA USA

[7] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA USA

[8] Univ Calif Berkeley, Ctr Computat Biol, Berkeley, CA USA

[9] Univ Minnesota Twin Cities, Inst Biol Aging & Metab, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA

[10] Ecole Polytech Fed Lausanne EPFL, Inst Bioengn, Sch Life Sci, Lab Syst Biol & Genet, Lausanne, Switzerland

[11] Natl Univ Singapore, Fac Sci, Dept Pharm & Pharmaceut Sci, Singapore, Singapore

[12] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Informat, Singapore, Singapore

[13] ASTAR, Genome Inst Singapore GIS, Singapore, Singapore

[14] Natl Univ Singapore, Yong Loo Lin Sch Med, Precis Med Translat Res Programme, Singapore, Singapore

[15] Natl Univ Singapore, Yong Loo Lin Sch Med, Cardiovasc Metab Dis Translat Res Programme, Singapore, Singapore

[16] Natl Univ Singapore, NUS Ctr Canc Res, Yong Loo Lin Sch Med, Singapore, Singapore

[17] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[18] Univ Michigan, Med Sch, Dept Pediat, Ann Arbor, MI USA

[19] Southern Med Univ, Zhujiang Hosp, Guangzhou, Peoples R China

[20] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia

[21] CSIRO, Human Hlth Hlth & Biosecur, Canberra, ACT, Australia

[22] Texas Tech Univ, Dept Vet Sci, Lubbock, TX USA

[23] Texas Tech Univ, Sch Vet Med, Amarillo, TX USA

[24] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[25] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX USA

[26] Univ Pittsburgh, Dept Med, Div Endocrinol, Pittsburgh, PA USA

[27] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem & Pharmacol, Beer Sheva, Israel

[28] NYU, Dept Mol Pathobiol, New York, NY USA

[29] NYU, Dept Cell Biol, Grossman Sch Med, New York, NY USA

[30] NYU, Grossman Sch Med, Dept Med, New York, NY USA

[31] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China

[32] Harvard Med Sch, Joslin Diabet Ctr, Res Div, Sect Integrat Physiol & Metab, Boston, MA USA

[33] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Med Huddinge H7, Huddinge, Sweden

[34] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[35] Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark

[36] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO USA

[37] Karolinska Inst, Dept Physiol & Pharmacol, Mol & Cellular Exercise Physiol, Stockholm, Sweden

[38] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI USA

[39] Aarhus Univ, Ctr Quantitat Genet & Genom, Aarhus, Denmark

[40] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zentrum Munchen, Leipzig, Germany

[41] Univ Hosp Leipzig, Leipzig, Germany

[42] Sidra Med, Doha, Qatar

[43] Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT USA

[44] Hamad Bin Khalifa Univ, Coll Hlth & Life Sci, Doha, Qatar

[45] German Ctr Neurodegenerat Dis DZNE, Immunogen & Neurodegenerat, Bonn, Germany

[46] German Ctr Neurodegenerat Dis DZNE, Platform Single Cell Genom & Epigen PRECISE, Bonn, Germany

[47] Univ Bonn, Bonn, Germany

[48] West German Genome Ctr WGGC, Bonn, Germany

[49] McMaster Univ, Ctr Burn Res, Hamilton Hlth Sci Ctr, Dept Surg, Hamilton, ON, Canada

[50] McMaster Univ, Dept Biochem, Hamilton, ON, Canada

来源：

NATURE METABOLISM | 2025年 / 7卷 / 05期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

INSULIN-RESISTANCE; REGIONAL-VARIATION; BROWN; FAT; DISTINCT; BEIGE; GAMMA; IDENTIFICATION; ADIPOCYTES; REVEALS;

D O I：

10.1038/s42255-025-01296-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.

引用

页码：875 / 894

页数：20

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