A new lupane glycoside isolated from Dendrobium officinale withα-glucosidase inhibitory activity

被引：0
作者：
Yen, Pham Hai [1 ]
Hang, Dan Thi Thuy [1 ]
Tra, Dinh Thu [1 ]
Hoang, Nguyen Huy [1 ]
Bang, Ngo Anh [1 ]
Dung, Nguyen Viet [1 ]
Huong, Phan Thi Thanh [1 ]
Yen, Duong Thi Hai [1 ]
Dung, Duong Thi [1 ]
Trang, Do Thi [1 ]
Tai, Bui Huu [1 ]
Kiem, Phan Van [1 ]
机构：
[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam
来源：
VIETNAM JOURNAL OF CHEMISTRY | 2025年
关键词：
Dendrobium officinale; dendrolupanoside; lupane triterpenoid; Orchidaceae; alpha-glucosidase inhibitory activity; TRITERPENOID SAPONINS;
D O I：
10.1002/vjch.70020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new lupane triterpene glycoside (1) and four known compounds (2-5) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be 3-O-alpha-L-arabinopyranosylbetulinic acid 28-O-beta-D- glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (1), 3-O-alpha-L-arabinopyranosylbetulinic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta- D-glucopyranosyl ester (2), 3-O-beta-D-glucopyranosylbetulinic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (3), 6 alpha-hydroxylup-20(29)-en-3-on 28-oic acid (4), and lupeol (5) by analyzing the HR-ESI-MS, 1D and 2D NMR spectra including COSY and NOESY. Compounds 1, 2 and 4 showed weak alpha-glucosidase inhibitory activity with IC50 values ranging from 87.5 to 98.2 mu M.
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页数：7
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