A new lupane glycoside isolated from Dendrobium officinale withα-glucosidase inhibitory activity

被引：0

作者：

Yen, Pham Hai ^{[1
]}

Hang, Dan Thi Thuy ^{[1
]}

Tra, Dinh Thu ^{[1
]}

Hoang, Nguyen Huy ^{[1
]}

Bang, Ngo Anh ^{[1
]}

Dung, Nguyen Viet ^{[1
]}

Huong, Phan Thi Thanh ^{[1
]}

Yen, Duong Thi Hai ^{[1
]}

Dung, Duong Thi ^{[1
]}

Trang, Do Thi ^{[1
]}

Tai, Bui Huu ^{[1
]}

Kiem, Phan Van ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2025年

关键词：

Dendrobium officinale; dendrolupanoside; lupane triterpenoid; Orchidaceae; alpha-glucosidase inhibitory activity; TRITERPENOID SAPONINS;

D O I：

10.1002/vjch.70020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new lupane triterpene glycoside (1) and four known compounds (2-5) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be 3-O-alpha-L-arabinopyranosylbetulinic acid 28-O-beta-D- glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (1), 3-O-alpha-L-arabinopyranosylbetulinic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta- D-glucopyranosyl ester (2), 3-O-beta-D-glucopyranosylbetulinic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (3), 6 alpha-hydroxylup-20(29)-en-3-on 28-oic acid (4), and lupeol (5) by analyzing the HR-ESI-MS, 1D and 2D NMR spectra including COSY and NOESY. Compounds 1, 2 and 4 showed weak alpha-glucosidase inhibitory activity with IC50 values ranging from 87.5 to 98.2 mu M.

引用

页数：7

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