Diabetes-induced depression: unravelling the role of gut dysbiosis

被引:0
作者
Sharma, Vivek Kumar [1 ]
机构
[1] Govt Coll Pharm, Dept Pharmacol, Rohru 171207, Himachal Prades, India
关键词
Diabetes; Depression; Dysbiosis; Inflammation; Microbiota; Gut-brain axis; HPA axis; PITUITARY-ADRENAL AXIS; HIPPOCAMPAL NEUROGENESIS; GLUCOCORTICOID-RECEPTOR; INTESTINAL MICROBIOME; GLUCOSE-METABOLISM; MEXICAN-AMERICANS; PROTEIN-LEVELS; BILE-ACIDS; TNF-ALPHA; INSULIN;
D O I
10.1007/s40200-025-01643-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Depression is a prevalent yet often underdiagnosed neuropsychiatric comorbidity of type 2 diabetes mellitus (T2DM), significantly complicating disease management, treatment adherence, and overall well-being. Emerging evidence suggests that gut microbiota dysbiosis plays a pivotal role in linking T2DM and depression through mechanisms such as epithelial barrier dysfunction, systemic inflammation, neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and impaired neurogenesis. This review aims to explore the mechanistic pathways through which diabetes-induced dysbiosis contributes to depression and to appraise the therapeutic potential of microbiota-targeted interventions, including probiotics, prebiotics, and fecal microbiota transplantation, in mitigating depressive symptoms and improving metabolic outcomes. Understanding this gut-brain interplay may provide novel insights into therapeutic strategies for managing the dual burden of diabetes and depression.
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页数:23
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