The Structure and Functional Changes of Thyroid in Severe Acute Pancreatitis Rats

被引：0
作者：
Yang, Bo [1 ]
Qiao, Huanyu [1 ]
Liu, Yongmin [1 ]
Wang, Xiaona [2 ]
Peng, Wenxing [3 ]
机构：
[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Anzhen Hosp, Dept Anesthesia, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Anzhen Hosp, Dept Pharm, Beijing, Peoples R China
来源：
PHYSIOLOGICAL RESEARCH | 2025年 / 74卷 / 01期
关键词：
Severe acute pancreatitis; Thyroid; Structure and functional changes; Transmission electron microscopy; HORMONE; CALCIUM; CELLS;
D O I：
10.33549/physiolres.935403
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Severe acute pancreatitis (SAP) is associated with metabolic disorders, hypocalcemia, and multiple organ failure. The objective of this study was to investigate changes in thyroid ultrastructure and function in rats with SAP and to provide a theoretical basis for the clinical treatment of thyroid injury in patients with SAP. 64 male SPF Wistar rats were randomly divided into the SAP group and the control group. Pancreatic enzymatic indicators and thyroid hormones were detected, pathology scores were evaluated, and morphological changes were observed under light microscopy and transmission electron microscopy (TEM) in both groups. The serum levels of triiodothyronine (T3), tetraiodothyronine (T4) and Ca2+ were significantly lower in the SAP group than in the control group (P<0.05), whereas the level of calcitonin (CT) was significantly higher than that in the control group (P<0.05). The thyroid structure (pathology and electron microscopy) of the SAP rats was seriously damaged and worsened over time. SAP can cause thyroid injury through a variety of mechanisms, which can also retroact to pancreatitis to aggravate the inflammatory response. This study may have theoretical significance for basic research on SAP.
引用
收藏
页码：105 / 114
页数：10
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