Speech Differences between Multiple System Atrophy and Parkinson's Disease

被引：0

作者：

Haehnel, Tom ^{[1
,2
]}

Nemitz, Anna ^{[1
,2
]}

Schoen, Katja ^{[3
]}

Berger, Luise ^{[3
,4
]}

Vogel, Annemarie ^{[3
]}

Gruber, Doreen ^{[3
,4
]}

Schnalke, Nils ^{[1
,2
]}

Braeuer, Stefan ^{[1
,2
,5
]}

Falkenburger, Bjoern H. ^{[1
,2
,5
]}

Gandor, Florin ^{[3
,4
,6
]}

机构：

[1] TUD Dresden Univ Technol, Med Fac, Dept Neurol, Dresden, Germany

[2] TUD Dresden Univ Technol, Univ Hosp Carl Gustav Carus, Dresden, Germany

[3] Kliniken Beelitz GmbH, Movement Disorders Hosp, Beelitz, Germany

[4] Otto von Guericke Univ, Dept Neurol, Magdeburg, Germany

[5] German Ctr Neurodegenerat Dis DZNE, Dresden, Germany

[6] Macquarie Univ, Dept Neurol, Suite 204,Level 2,2 Technol Pl, Sydney, NSW 2109, Australia

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2025年

关键词：

Parkinson's disease; multiple system atrophy; speech; dysarthria; voice; PROGRESSIVE SUPRANUCLEAR PALSY; NATURAL-HISTORY; VALIDATION; PATTERNS; CRITERIA;

D O I：

10.1002/mdc3.70094

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited. Objectives: To determine whether speech characteristics can serve as a digital biomarker to differentiate between MSA and PD. Methods: Twenty-one MSA patients and 23 PD patients underwent a battery of speech assessments: text reading, sustained phonation and diadochokinetic tasks. Speech characteristics were extracted using the software, Praat. Results: MSA and PD speech can be described by three meaningful factors. MSA speech exhibited more reading pauses, higher pitch variability, prolonged syllables, and a more irregular speech rhythm, allowing differentiation from PD with a ROC-AUC of 0.89. Speech characteristics were correlated with motor impairment and disease severity. Conclusion: MSA can be differentiated from PD with good accuracy using speech analysis.

引用

页数：7

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